Observational Study of CS Reducer for Heart Failure with Preserved Ejection Fraction

This observational study is looking at how a CS reducer affects people with a type of heart failure called Heart Failure with Preserved Ejection Fraction (HFpEF) and Coronary Microvascular Dysfunction (CMD). These conditions mean your heart can't pump blood effectively, even though it looks like it's squeezing normally, and the small blood vessels in your heart aren't working right. The study aims to see if the CS reducer helps improve blood flow to the heart muscle. To join, you must be at least 18 years old and already enrolled in a separate study (IRB# 25-002292). The study will measure changes in blood flow to the heart muscle using a special MRI scan. The current status of this study is unclear, and it plans to include 25 participants.

Study design
This is an observational study, meaning researchers will watch and collect information without giving a specific treatment within this study. It plans to include 25 participants.
What's involved
You would undergo a 50-minute non-invasive stress perfusion Cardiovascular Magnetic Resonance (CMR) scan at the beginning and again at 6 months.
Compensation
Not stated in the trial record.
Follow-up
Your heart's blood flow will be measured at the start of the study and again after 6 months.

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NCT07093528

A Study Of CS Reducer For Symptomatic Heart Failure With HFpEF And CMD

Recruiting
Not specifiedAges 18+Observational
Mayo Clinic
~25 participants
Updated 2026-02-27 on ClinicalTrials.gov
What's tested:Cardiovascular Magnetic Resonance (CMR)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in endocardial:epicardial perfusion ratio
Measured over Baseline, 6 Months
Heart Failure With Preserved Ejection Fraction
Coronary Microvascular Dysfunction
1 sites across 1 states
Minnesota1
  • Claire Raphael, M.B.B.S., Ph.D. · PRINCIPAL_INVESTIGATOR · Mayo Clinic

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Eligibility criteria

Inclusion

Age ≥18
Enrollment in main CS-reducer HFPEF study IRB# 25-002292

Exclusion

Metal implants that are not suitable for MRI
Inability or unwillingness of individual to give written informed consent.
  • Change in endocardial:epicardial perfusion ratioBaseline, 6 Months

    Endocardial:Epicardial Perfusion Ratio is a measure of myocardial blood flow and will be determined by Cardiovascular magnetic resonance (CMR)