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Understanding Brain Function and Behavior in Emerging Adults

This study aims to understand how personality, brain function, and behavior are connected in young adults aged 18-22. Researchers are looking at how different ways of processing information, called "sign-tracking" and "goal-tracking," relate to attention, impulse control, and how the brain responds to rewards. You would have your brain scanned using an fMRI (functional magnetic resonance imaging), wear skin sensors, and complete questionnaires and behavioral tasks while your eye movements are tracked. The study is looking for a connection between a specific score related to how you respond to cues (Pavlovian conditioned approach bias score) and your cannabis use. The study is currently unclear about its recruitment status and plans to enroll 294 participants.

Study design
This interventional study plans to enroll 294 participants. It is not specified if it is randomized or blinded.
What's involved
You would have multiple visits, including an fMRI scan lasting about 90 minutes, and complete questionnaires and behavioral tasks with eye tracking.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07094061

Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model

Recruiting
NAAges 18–22InterventionalBasic science
University of Michigan
~294 participants
Updated 2026-06-10 on ClinicalTrials.gov
What's tested:fMRIQuestionnaires and surveysBehavioral tasks and eye tracking

At a glance

Recruiting sites
1 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Correlation between Pavlovian conditioned approach (PavCA) bias score (out-of-scanner) and composite cannabis use score
Measured over Baseline

Conditions

Substance Use
Healthy

Explore related trials

Substance Use

Where it's being run

2 sites across 1 states
Michigan2

Study leadership

  • Lora Cope, PhD · PRINCIPAL_INVESTIGATOR · University of Michigan

Who to contact

Paul Holdefer, MPH
[email protected]
734-998-9239
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

18-22 years old at baseline
Right-handed
Medically/physically able to give informed consent
English-speaking
Substance use is free to vary, but for participants with a history of substance use, ≥ 1 use of cannabis (including less than a full dose)

Exclusion

Acute or chronic medical or neurological illness (e.g., diabetes, epilepsy, migraine)
History of psychosis in self or first-degree relative
Current treatment for substance use disorder
Current or past 6-month treatment with centrally acting medications (not including attention deficit hyperactivity disorder (ADHD) medication)
Intelligence quotient (IQ) \< 70
Lifetime history of head trauma with loss of consciousness \> 5 minutes
Reliance on glasses to be able to read small text at a distance of approximately 30 inches
Colorblindness
MRI contraindication (e.g., pregnancy, metal implants, claustrophobia) per protocol

What this trial measures

  • Correlation between Pavlovian conditioned approach (PavCA) bias score (out-of-scanner) and composite cannabis use scoreBaseline

    PavCA bias score based on eye gaze during the Pavlovian conditioned approach task will be correlated with a cannabis use composite score based on the Substance Use History and Timeline Follow-Back.