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Jaw Muscle Pain After Wisdom Tooth Surgery

This study is looking at ways to reduce jaw muscle pain after wisdom tooth removal. It will test if a Temporo-masseteric Nerve Block (TMNB) injection, which uses 2% lidocaine with 1:100,000 epinephrine, can help. Some participants will receive this injection, while others will receive a placebo (a shot of saline) or only oral pain medications. The study aims to see if the injection reduces jaw muscle pain, improves mouth opening, and lowers the amount of pain medication needed. You might be able to join if you are 18 or older, healthy, and having at least one lower wisdom tooth removed under sedation. The main goal is to measure how much jaw muscle pain is reduced 15 minutes after the injection on Day 2. The study status is currently unclear.

Study design
This is a triple-blind, placebo-controlled randomized study involving 80 participants. This means neither you, your doctor, nor the study staff will know if you receive the active injection or a placebo.
What's involved
You will have wisdom tooth surgery, and if you have significant jaw muscle pain the next day, you might receive an injection. You will also complete daily assessments and return for a final evaluation on Day 8.
Compensation
Not stated in the trial record.
Follow-up
You will have a final evaluation on Day 8 after your surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07094542

Jaw Muscle Pain Post Wisdom Molar Surgery

Not Yet Recruiting
PHASE2Ages 18+InterventionalTreatment
Rutgers, The State University of New Jersey
~80 participants
Updated 2026-06-18 on ClinicalTrials.gov
What's tested:Temporo-masseteric Nerve Block InjectionOral Pain Medications only

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Jaw Muscle Pain Reduction on palpation post-TMNB injections
Measured over Day 2 15 minutes post TMNB injection

Conditions

Post Operative Pain
Impacted Third Molar Tooth
Muscle Pain

Explore related trials

Impacted third molar toothJaw Muscle PainMyalgiaPost-Operative Pain

Where it's being run

1 sites across 1 states
New Jersey1

Who to contact

Gayathri D Subramanian, PhD, DMD
[email protected]
7328247241
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

are 18 years or older,
are healthy,
have no cognitive/intellectual disability,
have no past/recent pain or reduced range of motion in their jaw joint/ muscle complex, no trauma or surgery in their jaw region.
have an electronic device such as a smart phone or a tablet/ computer with internet connection.
are willing to participate in the study and not be excluded by the following criteria below.

Exclusion

Compromised ability to guard their self-interest, for e.g., prisoners, children, pregnant women, patients with intellectual/cognitive disability are not enrolled in the study.
Those patients who present with infection/inflammation involving the third molars slated for extractions, on the day of their procedure, may not take part in the study.
Those who have had opioid pain medication/s in the past 3 months to address short term or long-standing pain, or those who are on long term prescription of anti-inflammatory pain medication, are unable to participate.
Those with long standing painful limitation of movement of the jaw joint or muscles.
Those patients who are allergic to/unable to tolerate either the dental local anesthetic or its components, opioids, acetaminophen or ibuprofen also may not take part in the study

What this trial measures

  • Jaw Muscle Pain Reduction on palpation post-TMNB injectionsDay 2 15 minutes post TMNB injection

    To assess the effect of TMNB injection on the Numerical Pain Rating Scale (NRS) corresponding to Jaw muscle pain-to-palpation reported by the participant, when assessed 15 minutes post-injection.