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Nd:YAG Laser Photobiostimulation for Gum Healing After Tooth Extraction

This study is looking at whether a special laser treatment, called Nd:YAG laser photobiostimulation, can help your gums heal better and faster after a tooth extraction (removal) and alveolar ridge preservation (ARP). ARP is a procedure to maintain the bone and gum shape after extraction, often before a dental implant. Researchers will apply the laser on the day of your extraction, and then again on day 3 and day 7. They will measure inflammation in your saliva, the size of your wound, and your pain levels to see if the laser treatment is helpful. You may be able to join if you are at least 18 years old, are scheduled for a tooth extraction and ARP, and can report your pain level. The study aims to enroll 39 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 39 participants.
What's involved
You would receive low-level laser applications on the day of your tooth extraction, and then again on day 3 and day 7.
Compensation
Not stated in the trial record.
Follow-up
Your inflammatory markers in saliva will be measured through day 7, wound size changes through day 42, and post-operative pain through day 14.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07095556

Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva

Recruiting
NAAges 18+InterventionalTreatment
Medical University of South Carolina
~39 participants
Updated 2025-11-12 on ClinicalTrials.gov
What's tested:Low-level laser therapy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Inflammatory markers in saliva
Measured over From day of tooth extraction through day 7
+2 more outcomes measured

Conditions

Wound Healing and Prevention
Oral Inflammation
Photobiomodulation
Post-operative Pain Management
Tooth Extraction Site Healing

Explore related trials

Extraction of ToothPeriodontal DisorderPortal inflammationWound healed

Where it's being run

1 sites across 1 states
South Carolina1

Study leadership

  • Pinar Emecen-Huja · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina

Who to contact

Pinar Emecen-Huja
[email protected]
(843) 792-5688
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Participants who are ≥ 18 years old,
Patients who are scheduled for the treatment of tooth extraction and alveolar ridge preservation (ARP)
No contraindications for tooth extraction and alveolar ridge preservation based on electronic health records.
Participants who can express the level of pain
Participants who self-report "not pregnant"

Exclusion

Untreated periodontal disease
Acute infection of the teeth
Use of antibiotics within the last three months.
Pregnant or lactating women
Use of bisphosphonates based on EHR
Alveolar bone defects occurred or were detected during tooth extraction

What this trial measures

  • Inflammatory markers in salivaFrom day of tooth extraction through day 7

    The measurement of inflammatory and anti-inflammatory markers in saliva, IL-1β, IL-6, IL-8, IL-10, IL-12 and TNF secreted during the early stages of wound healing at day 3 and day 7.

  • Wound size dimensional changesFrom the day of tooth extraction to day 42

    The comparison of dimensional changes in wound size between test and intervention groups. Digital gingival scans of the wound will be taken immediately after surgery and at days 3, 7, 14, and 42 for Aim 2.

  • Post-operative painFrom post-operative day 3 to day 14

    Recording of pain perception using a Visual Analog Scale at visits 3, 7, and 14 (maximum pain being 10 vs. no pain being 0), 2)