The WiSE®-UP Registry for Heart Failure

This registry is studying the WiSE CRT System, an implantable device that helps your heart pump blood more effectively. It works by providing electrical stimulation to both the left and right sides of your heart (biventricular pacing). The goal is to understand how well the WiSE System performs in real-world use, including its safety and how it affects patients with heart failure. You may be able to join if you are planned to receive a WiSE System and meet certain screening requirements. The study will track safety over several years, up to 60 months. The current recruitment status is unclear.

Study design
This is an observational study, meaning researchers will watch and collect information about patients using the WiSE System. It plans to enroll 320 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for safety at 1, 6, 12, 24, 48, and 60 months after receiving the device.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07098858

The WiSE®-UP Study (The WiSE System Utilization & Performance Study)

Recruiting
Not specifiedAges 22+Observational
EBR Systems, Inc.
~320 participants
Updated 2026-09-10 on ClinicalTrials.gov
What's tested:The Wise System

At a glance

Recruiting sites
11 of 12 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Primary Safety
Measured over 1, 6, 12, 24, 48 and 60 months
Heart Failure

NCT07098858

Where you'd take part

This study runs at 12 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Arrhythmia Research Group (St. Bernards Hospital)

    Jonesboro, Arkansasstudy coordinator listed

    Recruiting

  • CardioVascular Associates of Mesa (CVAM)

    Mesa, Arizonastudy coordinator listed

    Not yet recruiting

  • Cleveland Clinic Foundation

    Cleveland, Ohiostudy coordinator listed

    Recruiting

  • Honor Health

    Scottsdale, Arizonastudy coordinator listed

    Recruiting

  • MUSC

    Charleston, South Carolinastudy coordinator listed

    Recruiting

  • Naples Community Hospital

    Naples, Floridastudy coordinator listed

    Recruiting

  • Penn State Health

    Hershey, Pennsylvaniastudy coordinator listed

    Recruiting

  • St. Luke's Hospital of Kansas City

    Kansas City, Missouristudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Opens a ready-to-send draft in your own email app — review before sending.

  • Primary Safety1, 6, 12, 24, 48 and 60 months

    The primary outcome measure of the Study is the rate of serious adverse events (SAEs) at \< 30 days post implant related to the WiSE System and/or implant procedure.