This observational study is looking at how proteins called amyloids, which build up in the brain as people get older, might be connected to changes in memory and thinking abilities. Researchers are using special imaging scans, called PET scans, with tracers like (11C) Pittsburgh compound B (PiB) and (18F) florbetaben (Neuraceq™), to track these amyloids over time. The goal is to understand if changes in amyloid levels predict who might develop problems with their memory or thinking as they age. You can join if you are 55 years or older and are already part of the Baltimore Longitudinal Study of Aging. This study is currently ongoing, but the exact status is unclear.

Study design

This is an observational study planning to enroll 400 participants. It is not a randomized or blinded study.

What's involved

You will have imaging scans and other tests every 1 to 4 years, depending on your age. If you are 80 or older, you will be scanned yearly.

Compensation

Not stated in the trial record.

Follow-up

Amyloid accumulation will be measured longitudinally, meaning over an extended period of time.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.