Image Detection of Impaired Microcirculatory Reperfusion in Ischemic Stroke

This study is looking at how well a special type of imaging, called CT Perfusion, can detect problems with blood flow in the brain after a stroke. Specifically, it's for people who have had an acute ischemic stroke (a stroke caused by a blood clot) due to a large vessel occlusion (LVO), meaning a major blood vessel in the brain was blocked. The study will use CT Perfusion within 90 minutes after a procedure to remove the blood clot. Researchers want to see if this imaging can identify a specific sign (a "radiographic biomarker") that shows if blood flow isn't fully restored at a very small level, and how this relates to brain damage. You can join if you are an adult aged 18 or older, had your stroke within 24 hours of your last known normal time, and meet specific criteria for the type of stroke and how well the clot removal procedure worked. The study aims to see if this imaging method is practical to use.

Study design: This is an observational study, meaning researchers will observe participants without assigning specific treatments. It plans to enroll 40 participants.
What's involved: Not specified in the trial record.
Compensation: Not stated in the trial record.
Follow-up: Participants will be followed from enrollment up to 96 hours, which includes an MRI between 48 and 96 hours.

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Image Detection of Impaired Microcirculatory Reperfusion

Recruiting

Not specifiedAges 18+Observational

University of Cincinnati

~40 participants

Updated 2025-08-01 on ClinicalTrials.gov

What's tested:CT Perfusion

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Feasibility of 90-minute CTP and 48-96-hr MRI

Measured over From enrollment to 96 hours

Conditions

Ischemic Stroke, Acute

Large Vessel Occlusion

Where it's being run

1 sites across 1 states

Ohio1

Who to contact

Yasmin N Aziz, MD

[email protected]

513-688-5405

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Eligibility criteria

Inclusion

Adults greater than or equal to 18 years of age

Last known normal (LKN) within 24 hours

Ischemic stroke due to anterior circulation LVO (intracranial internal carotid artery \[ICA\], proximal middle cerebral artery \[M1\], M1/M2 bifurcation, or proximal dominant M2 occlusion)

mTICI2c or mTICI3 on digital subtracted angiography (DSA) following mechanical thrombectomy

Exclusion

Significant renal insufficiency (glomerular filtration rate \<30mg/ml/min2 while not on dialysis)

Contraindication to iodinated contrast

Contraindication to magnetic resonance imaging (e.g., pacemaker incompatibility)

Prior significant stroke in same vascular territory ipsilateral stroke

Tandem vessel occlusion (i.e., extracranial ICA and ipsilateral intracranial M1/M2 occlusion)

Greater than 4 clot retrieval attempts

Enrollment in another acute stroke interventional study (with the exception of thrombectomy device registries)

Pregnancy

Prisoners

What this trial measures

Feasibility of 90-minute CTP and 48-96-hr MRIFrom enrollment to 96 hours
The primary outcome is feasibility determined by greater than or equal to 80% of the planned sample size for whom technically adequate 90-minute CTP and 48-96 hour MRI key parameters (baseline penumbra volume \[Tmax greater than 4 seconds\], predicted infarct core volume \[CBF greater than 30%\], and follow-up infarct volume \[MRI DWI\]) are usable.

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