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Post-cesarean Pain Management: Staggered vs. Simultaneous Therapies

This study is looking at the best way to give pain medication after a cesarean delivery (C-section). Researchers want to see if giving acetaminophen (Tylenol) and NSAIDs (like ibuprofen or ketorolac) at different times (staggered) works better for pain control than giving them at the same time (simultaneous). You might be able to join if you are at least 16 years old, are at least 34 weeks pregnant with one baby, and are having a C-section with regional anesthesia. The study will measure your pain levels 48 hours after delivery and how much opioid pain medication you use until you leave the hospital. The study plans to include 825 women, but its current status is unclear.

Study design
This is an interventional study that plans to enroll 825 participants to compare two different dosing schedules for pain medication after C-section.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your pain control will be measured at 48 hours after delivery, and opioid consumption will be tracked until you are discharged from the hospital (typically 2-5 days).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07102641

Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies

Active, Not Recruiting
PHASE4Ages 16+InterventionalTreatment
Thomas Jefferson University
~825 participants
Updated 2026-08-31 on ClinicalTrials.gov
What's tested:AcetaminophenNSAID (Ketorolac/Ibuprofen)

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Postpartum pain control
Measured over 48 (+/- 4) hours postpartum
+1 more outcome measured

Conditions

Cesarean Delivery
Postpartum Comfort
Postpartum Pain
Post-operative Pain
NSAIDs
Acetaminophen (D000082)

Explore related trials

Deliveries by cesareanPost-Operative Pain

Where it's being run

1 sites across 1 states
Pennsylvania1

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

\>/= 34 weeks gestation
Singleton pregnancy
Delivery via cesarean section under regional anesthesia

Exclusion

Contraindication to acetaminophen or NSAIDs
Current or history of opioid use or misuse
Intrauterine fetal demise
Major congenital anomaly
Conversion to general anesthesia intra-op or planned general anesthesia
Mid-line vertical skin incision
Receipt of intraoperative local analgesia such as Transversus Abdominis Plan (TAP) block or wound infiltration

What this trial measures

  • Postpartum pain control48 (+/- 4) hours postpartum

    Visual analog pain score (VAS) with movement. Scale ranges from 0-10 with 0 indicating no pain and 10 indicating worst possible pain

  • Opioid consumptionPostpartum Admission (From time of surgery to hospital discharge; typically 2-5 days)

    Opioid consumption (in total morphine milligram equivalents (MME))