Parathyroidectomy and Mobility Study for Hyperparathyroidism
This study is looking at whether surgery to remove the parathyroid gland (parathyroidectomy) can improve how well older adults with primary hyperparathyroidism (PHPT) move and function. PHPT is a common condition in older adults that can affect muscle strength and mobility. Researchers will observe up to 80 participants, aged 60 and older, who are already having parathyroidectomy at UF Health. You would have physical tests, wear a device to track activity, and give blood samples before and after surgery. The goal is to understand changes in physical function after surgery and find markers in the blood that might predict better mobility. The study is currently unclear on its recruitment status.
- Study design
- This is an observational study involving up to 80 participants. It is not specified whether it is randomized or blinded.
- What's involved
- You would complete physical performance tests, wear an Actigraph device, and provide blood samples at pre-operative assessment and at 3 months post-operative assessment.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 3 months after their surgery.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Parathyroidectomy and Mobility Study
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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What this trial measures
- Distance Walked in Six-Minute Walk Test (6MWT)At pre-operative assessment and at 3 month post-operative assessment
Measures walking endurance and aerobic capacity by recording the distance walked in six minutes along a 20-meter course.
- Short Physical Performance Battery ScoreAt pre-operative assessment and at 3 month post-operative assessment
A composite test assessing balance, gait speed (4-meter walk), and lower body strength (chair stands). Higher scores reflect better function.
- Isokinetic Knee Strength (Biodex)At pre-operative assessment and at 3 month post-operative assessment
Assesses lower limb muscle strength and endurance using a dynamometer. Reports peak torque and fatigue index.
- Grip StrengthAt pre-operative assessment and at 3 month post-operative assessment
Handgrip strength is measured using a dynamometer as a marker of overall muscle strength and frailty risk.
- Intensity of Movement using ActiGraph AccelerometryAt pre-operative assessment and at 3 month post-operative assessment
An objective measure of free-living physical activity using a wearable hip device that captures intensity of movement over 7 days.
- Frequency of Movement using ActiGraph AccelerometryAt pre-operative assessment and at 3 month post-operative assessment
An objective measure of free-living physical activity using a wearable hip device that captures frequency of movement over 7 days.
- Duration of Movement using ActiGraph AccelerometryAt pre-operative assessment and at 3 month post-operative assessment
An objective measure of free-living physical activity using a wearable hip device that captures duration of movement over 7 days.
- CHAMPS Questionnaire ScoreAt pre-operative assessment and at 3 month post-operative assessment
A validated self-report tool for older adults that measures weekly frequency and duration of common physical activities.
- Pasieka Parathyroidectomy Assessment of Symptoms (PAS)At pre-operative assessment and at 3 month post-operative assessment
A validated 13-item questionnaire measuring severity of neurocognitive and neuromuscular symptoms common in PHPT, such as fatigue, irritability, and memory loss.
- Concentration of Plasma Cytokine BiomarkersBlood work will be collected at the pre-operative assessment, the 2 week post-operative assessment, 3 month post-operative assessment and the 6 month post-operative assessment
Blood-based analysis of myokines (e.g., IL-6, myostatin, LIF, irisin), osteokines (e.g., IGF-1, FGF-21, osteocalcin), and adipokines (e.g., adiponectin, TNF-α) associated with muscle-organ crosstalk, inflammation, and mobility.