Preventing Bite Changes with MAD Use for Sleep Breathing Disorders

This study is looking at two ways to prevent bite changes (occlusal changes) that can happen when using a Mandibular Advancement Device (MAD) for sleep-related breathing disorders like obstructive sleep apnea (OSA). While MADs help with breathing during sleep, they can sometimes change how your teeth fit together. You would be randomly assigned to either use an AM Aligner (an interocclusal aligner) every morning after removing your MAD, or to do daily jaw exercises. Both methods aim to reduce the risk of these bite changes. The study will follow participants for 3 months and involves dental checks, 3D scans of your mouth, and short daily surveys. To join, you must be an adult (18 or older) diagnosed with a sleep-related breathing disorder and prescribed MAD therapy, with most of your natural teeth.

Study design
This is an interventional study with 30 participants. You would be randomly assigned to one of two standard care approaches.
What's involved
You would participate for 3 months, including dental evaluations, 3D oral scans, and short daily surveys. You would also use an AM Aligner or perform daily jaw exercises.
Compensation
Not stated in the trial record.
Follow-up
The study measures the number of participants enrolled at 3 months, indicating the follow-up period.

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NCT07103941

IOA Preventing Occlusal Changes With MAD Use

Recruiting
NAAges 18+InterventionalPrevention
Isabel Moreno Hay
~30 participants
Updated 2026-05-18 on ClinicalTrials.gov
What's tested:AM AlignerExercise

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of participants enrolled in the study
Measured over 3 months
Sleep Related Breathing Disorder
Snoring
Obstructive Sleep Apnea (OSA)
Open Bite
Occlusal Changes
Tooth Migration
Posterior Open Bite
1 sites across 1 states
Kentucky1
  • Isable Moreno Hay, MS, PhD · STUDY_DIRECTOR · University of Kentucky

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Eligibility criteria

Inclusion

adult participants (≥18 years)
diagnosed with SRBD and prescribed Mandibular Advancement Device (MAD) therapy
Participants will include patients with well restored natural dentition with all posterior teeth, excluding third molars, one missing premolar secondary to orthodontic treatment.

Exclusion

pervious orthognathic surgery
anterior cross bite
posterior cross bite
existing open bite or implant supported restorations
tooth mobility
significant dental caries or periodontitis
severe bruxism
planned upcoming dental work including caps, crowns, implants, or braces
inadequate mandibular protrusion
severe micrognathia
large tori
significant claustrophobia
significant nasal obstruction
large oropharyngeal masses or large tonsils
  • Number of participants enrolled in the study3 months

    Recruitment will be measured by tracking the number of participants who agree to enroll in a randomized clinical trial comparing stretching exercises to the use of an interocclusal aligner (IOA).