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Antiseptic Washes and Wound Healing After Total Hip Replacement

This study is looking at how two different washing solutions, chlorhexidine and povidone-iodine, affect wound healing after total hip replacement surgery. These solutions are routinely used to clean the surgical area. Researchers want to find out if one solution leads to better healing and fewer complications. You could join if you are having a total hip replacement due to hip osteoarthritis or avascular necrosis (bone tissue death due to lack of blood supply) and have not responded to other treatments. The study will measure how well your surgical scar heals at 2 and 6 weeks after surgery. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 420 participants. Participants will be randomly assigned to receive either a chlorhexidine or povidone-iodine wash during surgery.
What's involved
You will undergo a standard total hip replacement surgery. Your surgical incision will be photographed at your 2-week and 6-week postoperative visits.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for at least 6 weeks after surgery, with scar assessments at 2 and 6 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07104084

Influence of Antiseptic Washes on Wound Healing Complications After THA

Recruiting
NAAges 18+InterventionalPrevention
F. Johannes Plate
~420 participants
Updated 2026-02-05 on ClinicalTrials.gov
What's tested:lavage chlorhexidinelavage povidone-iodine

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Patient and Observer Scar Assessment Scale
Measured over 2 weeks and 6 weeks postop

Conditions

Hip Osteoarthritis
Avascular Necrosis of Femur Head

Explore related trials

Avascular Necrosis of Femoral HeadHip Osteoarthritis

NCT07104084

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • UPMC East

    Monroeville, Pennsylvaniastudy coordinator listed

    Recruiting

  • UPMC Shadyside

    Pittsburgh, Pennsylvaniastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Frank J Plate, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh
  • Frank J Plate, MD, PhD · STUDY_DIRECTOR · University of Pittsburgh
  • Frank J Plate, MD, PhD · STUDY_CHAIR · University of Pittsburgh

Who to contact

Frank J Plate, MD, PhD
[email protected]
(412) 687-3900
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

osteoarthritis or avascular necrosis of the femoral head, failed conservative management, indicated for total hip replacement

Exclusion

reported or documented allergy to chlorhexidine or povidone-iodine

What this trial measures

  • Patient and Observer Scar Assessment Scale2 weeks and 6 weeks postop

    The observer scale of the POSAS consists of six items (vascularity, pigmentation, thickness, relief, pliability and surface area). All items are scored on a scale ranging from 1 ('like normal skin') to 10 ('worst scar imaginable'). The sum of the six items results in a total score of the POSAS observer scale. Categories boxes are added for each item. Furthermore, an overall opinion is scored on a scale ranging from 1 to 10. All parameters should preferably be compared to normal skin on a comparable anatomic location