Strength Training and GLP-1 Medications
This study is looking at how strength training affects muscle mass in people aged 50 and older who are taking GLP-1 medications like Wegovy or Zepbound for weight loss. Researchers want to see if these medications, which can sometimes reduce muscle, might be balanced by exercise. You could join if you are 50 or older, weigh less than 300 pounds, and have been taking a GLP-1 medicine for a month or less. The study will measure changes in your muscle mass and balance to see if strength training helps. The current recruitment status is unclear.
- Study design
- This interventional study plans to enroll 30 participants. Some will start strength training right away, while others will wait before beginning the program.
- What's involved
- You would participate in a 14-week strength training program, exercising three days a week with a personal trainer. You would also have two-hour lab testing sessions at the beginning and end of the 14 weeks to measure muscle mass and balance.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be assessed at baseline and after 14 weeks of intervention.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Strength Training Response of Muscle in GLP-1 Users
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Kevin Davy · PRINCIPAL_INVESTIGATOR · Virginia Polytechnic Institute and State University
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Muscle mass by d3-creatine dilutionWater containing creatine isotope consumed in lab; Urine sample collection on Day 0 and Day 3 at baseline and 14 weeks.
Participants will collect a urine sample prior to be provided a creatine capsule containing 30 milligrams of a naturally-occurring creatine isotope. A glass of water will be provided to wash it down. Participants will be asked to return \~3 days later to provide another urine sample. Urine samples will be analyzed at an off-site laboratory to determine changes in d3-creatine excretion before and after the 14-week strength training intervention.
- Balance testing - Percentage of failed recoveries2-hour testing session in lab at baseline and 14 weeks.
Participants will stand on the treadmill with the belt stationary. The belt will then suddenly change to a speed specified by the investigator, and the participant will attempt to step to maintain their balance and establish a stable gait. In addition to the treadmill itself, this system includes an integrated fall arrest harness that is anchored to an overhead gantry that is fixed to the treadmill. This harness prevents any body part but the feet from impacting the treadmill in the event that the participant is unable to maintain their balance after a sudden change in speed.