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Repetitive Transcranial Magnetic Stimulation for Stimulant Use Disorder

This study is testing a treatment called repetitive transcranial magnetic stimulation (rTMS) for Veterans with stimulant use disorder (SUD). rTMS is a non-invasive procedure that uses magnetic fields to create electrical currents in specific brain areas. Currently, there isn't an FDA-approved treatment for SUD, so this study aims to see if rTMS can be effective. You might be able to join if you are between 18 and 65 years old, have a severe SUD diagnosis, and your last stimulant use was between 2 and 8 weeks ago. The study will measure how many participants relapse (start using stimulants again) 3 months after their last rTMS treatment to see if the treatment works. The current enrollment status is unclear, but the study plans to include 106 participants.

Study design
This is a placebo-controlled study, meaning some participants will receive the active rTMS treatment and others will receive a sham (inactive) treatment. The study plans to enroll 106 participants.
What's involved
You would receive 30 rTMS or sham rTMS sessions over 2 weeks. These sessions involve a device that delivers magnetic stimulation to a specific brain region.
Compensation
Not stated in the trial record.
Follow-up
The study will follow up with participants for 3 months after their last rTMS treatment to measure relapse.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07112105

Repetitive Transcranial Magnetic Stimulation Treatment of Stimulant Use Disorder

Not Yet Recruiting
NAAges 18–65InterventionalTreatment
VA Office of Research and Development
~106 participants
Updated 2026-04-02 on ClinicalTrials.gov
What's tested:Repetitive transcranial magnetic stimulation (rTMS)Sham rTMS

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of Participants Relapsed
Measured over 3 months after last rTMS treatment

Conditions

Stimulant Use Disorder

Explore related trials

Stimulant use disorder

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Jong H. Yoon, MD · PRINCIPAL_INVESTIGATOR · VA Palo Alto Health Care System, Palo Alto, CA

Who to contact

Jong H Yoon, MD
[email protected]
(650) 493-5000
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Structured Clinical Interview for DSM Disorders (SCID) confirmed diagnosis of SUD, severe
Last use of stimulants \>2 and \<8 weeks
Stable medication regimen (no change in dose or agents between 2 weeks prior to the start of and throughout the treatment phase of the study)
Stable medical health

Exclusion

Pregnant or lactating female
History of prior adverse reaction to TMS
On medications thought to significantly lower seizure threshold, e.g. clozapine, chlorpromazine, clomipramine, and bupropion \> 400mg/day
Seizure disorder or conditions known to substantially increase risk for seizures
Implants or medical devices incompatible with TMS
Acute or unstable chronic medical illness that would affect participation or compliance in the study, e.g. unstable angina
Unstable psychiatric symptoms that precludes consistent participation in the study, e.g. active current suicidal intent or plan; severe psychosis
Other substance use disorder not in remission
Chronic or recurring Axis I psychotic disorders
For subjects participating in fMRI scans, presence of ferromagnetic material in their body or taking DAergic medications

What this trial measures

  • Number of Participants Relapsed3 months after last rTMS treatment

    Rate of stimulant use relapse compared between active vs. sham rTMS groups