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Optimal Ventilation for Pediatric Cardiac Arrest

This study is looking for children aged 37 weeks to 18 years who experience cardiac arrest (when the heart stops beating) and receive CPR. The goal is to see if a special training program called the OPTI-VENT Bundle can improve how many children survive to leave the hospital and have a good neurological outcome (brain function). The OPTI-VENT Bundle involves educating healthcare providers on the correct ventilation (breathing support) rates during CPR and providing them with cue cards. Some participants will receive this intervention, while others will receive standard care. The study aims to enroll 1530 children and will measure survival with good brain function at hospital discharge.

Study design
This is an interventional study aiming to enroll 1530 participants. It compares the OPTI-VENT Bundle intervention to standard care.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be assessed for survival with a favorable neurologic outcome at hospital discharge, which is estimated to be an average of 6-12 months from baseline.

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NCT07114510

Optimal Ventilation for Cardiac Arrest

Recruiting
NAAges 37–18Interventional
Children's Hospital of Philadelphia
~1,530 participants
Updated 2025-10-08 on ClinicalTrials.gov
What's tested:OPTI-VENT BundleTransitionNone - control

At a glance

Recruiting sites
20 of 20 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Survival with a favorable neurologic outcome
Measured over From baseline (assessed prior to admission, or new in-hospital baseline assessed no more than 30 days prior to cardiac arrest for patients hospitalized >90 days) to the assessment at hospital discharge, estimated average of 6-12 months

Conditions

Cardiac Arrest (CA)

Explore related trials

Cardiac Arrest

Where it's being run

20 sites across 16 states
Texas3
California2
Ohio2
Colorado1
Delaware1
Georgia1
Indiana1
Iowa1

Study leadership

  • Robert Sutton, MD, MSCE · PRINCIPAL_INVESTIGATOR · Children's Hospital of Philadelphia

Who to contact

CHOP RSC Clinical Research Program Manager
[email protected]
215-590-1859
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Eligibility criteria

Inclusion

Invasive airway in place at the start of CPR or airway placed within the first 5 minutes
Received at least 1 minute of CPR.

Exclusion

Lack of commitment to aggressive ICU therapies (e.g., CPR performed as part of end-of-life care.
Brain death determination prior to the CPR event.
Out-of-hospital cardiac arrest was the reason for initial admission to the hospital (known poor outcomes).
Supported by Veno-Arterial Extra Corporeal Membrane Oxygenation at the start of CPR

What this trial measures

  • Survival with a favorable neurologic outcomeFrom baseline (assessed prior to admission, or new in-hospital baseline assessed no more than 30 days prior to cardiac arrest for patients hospitalized >90 days) to the assessment at hospital discharge, estimated average of 6-12 months

    Survival to hospital discharge with a favorable neurologic outcome (Pediatric Cerebral Performance Category (PCPC) score (scored on a scale of 1-6) at hospital discharge of 1 (normal), 2 (mild disability) or no worse than baseline). Percentage of subjects in control vs. intervention will be compared.