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Intranasal Lidocaine for Headache After Brain Aneurysm Bleed

This study is looking at a new way to treat severe headaches that happen after a brain aneurysm bleeds (aneurysmal subarachnoid hemorrhage or aSAH). These headaches are often hard to treat with regular pain medicines, which can also have many side effects. Researchers are testing a treatment called an intranasal sphenopalatine ganglion block, which involves spraying lidocaine (a numbing medication) into the back of your nose. This aims to block nerves that cause head pain without the side effects of other pain medications. To join, you must be 18 or older, in the neurologic ICU for aSAH with mild to moderate symptoms (Hunt and Hess scale 0-3), and able to talk about your pain. The main goal is to see if this treatment reduces headache severity. The study plans to enroll 20 participants, and its current status is unclear.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to include 20 participants.
What's involved
You would receive the first treatment on the day you agree to participate, and a second treatment on day 4. Your pain will be recorded every 8 hours until you leave the ICU (about 2 weeks) and again 6 months after leaving the hospital.
Compensation
Not stated in the trial record.
Follow-up
Your headache pain will be monitored for about 2 weeks while in the ICU and again 6 months after you leave the hospital.

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NCT07116408

Intranasal Sphenopalatine Ganglion Blockade for Headaches Following Aneurysmal Subarachnoid Hemorrhage

Recruiting
PHASE4Ages 18+InterventionalTreatment
Wright State University
~20 participants
Updated 2026-05-27 on ClinicalTrials.gov
What's tested:Lidocaine (drug)Tx 360

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Headache severity
Measured over Day 1 (day of consent) Patient receives first treatment. Pain will be recorded every 8 hours. Second treatment is on day 4. Pain will be recorded every 8 hours until discharge from the ICU, an average of 2 weeks, and at 6 months post discharge.

Conditions

Aneurysmal Subarachnoid Hemorrhage (aSAH)
Headache

Explore related trials

HeadacheSubarachnoid Hemorrhage

Where it's being run

1 sites across 1 states
Ohio1

Who to contact

John B Terry, MD
[email protected]
937-208-4200
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Exclusion

Patients under the age of 18 years of age.
Patients with an allergy to lidocaine.
Patients from all vulnerable groups.
Patients with Hunt and Hess scale score of 4-5. (Scale ranges from 0 to 5 with higher numbers indicating more severe symptoms.)
Patients who are not able to consent.
Mentally impaired patients that are unable to provide consent.
Patients that are prisoners.
Pregnant patients.
History of recurrent nose bleeds.
Nasal septal deformity such as cleft lip and palate, choanal atresia (narrowed nasal passages), atrophic rhinitis, rhinitis medicamentosa, septal perforation, nasal/midface trauma.
Recent nasal/sinus surgery
Presence of a bleeding disorder (eg., Von Willebrand's disease or hemophilia).
Severe respiratory distress.
Presence of angiofibroma, sinus tumor, or granulomatous disease of the nasopharynx.
Presence of nasal trauma.
Nasal congestion that has been present more than 10 days, high fever, or abnormal appearance of the nasal mucosa or mucus.

What this trial measures

  • Headache severityDay 1 (day of consent) Patient receives first treatment. Pain will be recorded every 8 hours. Second treatment is on day 4. Pain will be recorded every 8 hours until discharge from the ICU, an average of 2 weeks, and at 6 months post discharge.

    Description of headache severity using the headache numerical rating scale. The scale is a subjective rating of headache pain. The scale ranges from 0-10 with 0 being no pain (minimum value, better outcome) and 10 being the worst pain imaginable (maximum value, worse outcome).