Rose Scent Exposure for Epilepsy and SUDEP Risk

This study is looking into whether exposure to rose scent (2-phenylethanol) can help reduce the risk of Sudden Unexpected Death in Epilepsy (SUDEP). SUDEP is a serious concern for people with epilepsy, and researchers want to see if this scent can affect breathing problems during seizures. You might be able to join if you are an adult with epilepsy, at least 18 years old, and admitted to the epilepsy monitoring unit (EMU) at Vanderbilt University Medical Center (VUMC) for observation. The study will measure the number of seizures and breathing episodes you have over 24 hours while exposed to the rose scent. The study is currently unclear about its recruitment status and plans to enroll 40 participants.

Study design
This is an interventional study, meaning participants will receive a specific intervention (rose scent). It is not specified if it is randomized or blinded, and it plans to enroll 40 participants.
What's involved
You would undergo 24 hours of routine monitoring, followed by 24 hours of monitoring with continuous rose scent exposure in your hospital room. You will also wear a respiratory monitoring belt for 48 hours.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes, such as the number of seizures and breathing episodes, are measured at 24 hours after the rose scent exposure begins.

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NCT07116421

Effect of Rose Odor Exposure on Ictal Apnea

Recruiting
EARLY_PHASE1Ages 18+InterventionalPrevention
Vanderbilt University Medical Center
~40 participants
Updated 2026-06-11 on ClinicalTrials.gov
What's tested:2-phenylethanol rose scent

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of ictal episodes
Measured over 24 hours
+1 more outcome measured
Epilepsy
Sudden Unexpected Death in Epilepsy
1 sites across 1 states
Tennessee1

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Eligibility criteria

Inclusion

Adult epilepsy patients over the age of 18
Admission to the inpatient epilepsy monitoring unit (EMU) at Vanderbilt University Medical Center (VUMC)
Undergoing observational EEG monitoring without treatment involving seizure medication changes or other interventions for at least 48 hours

Exclusion

Patients under the age of 18
Patients receiving EEG monitoring without interventions from baseline for less than 48 hours
Patients who are not receiving EEG monitoring as a part of their inpatient admission.
  • Number of ictal episodes24 hours

    Number of ictal episodes measured via EEG

  • Number of apneic episodes24 hours

    Number of brief cessations in breathing captured via respiratory belt