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Probenecid for Alcohol Craving and Consumption

This study is testing whether a medication called Probenecid can help reduce alcohol craving and consumption in people with Alcohol Use Disorder (AUD). Participants will receive either Probenecid (2 grams daily) or an inactive placebo tablet. The study aims to see if Probenecid decreases acute alcohol craving, general alcohol craving, and overall alcohol consumption. You may be able to join if you are at least 18 years old, meet specific criteria for moderate to severe AUD, and are in good health. The main goal is to measure changes in acute alcohol craving after 5 weeks. The current recruitment status is unclear.

Study design
This is a 16-week, double-blind, randomized controlled trial involving 120 participants. This means neither you nor the study staff will know if you are receiving Probenecid or the placebo.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint for acute alcohol craving is measured at 5 weeks.

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NCT07118618

Probenecid Administration for Alcohol Craving and Consumption

Recruiting
PHASE2Ages 18+InterventionalBasic science
Brown University
~120 participants
Updated 2026-03-17 on ClinicalTrials.gov
What's tested:Probenecid Oral TabletPlacebo Oral Tablet

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Acute Alcohol Craving
Measured over 5- week

Conditions

Alcohol Use Disorder (AUD)
Alcohol Consumption
Craving

Explore related trials

Alcohol use disorder

Where it's being run

1 sites across 1 states
Rhode Island1

Study leadership

  • Carolina Haass-Koffler, PharmD, PhD · PRINCIPAL_INVESTIGATOR · Brown Univiversity

Who to contact

Brian Gully, MA
[email protected]
401-863-6646
Email the study team

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Eligibility criteria

Inclusion

• Male or female, ≥18 years.
women \>7 drinks/week; men \>14 drinks/week.
meet moderate to severe AUD score for DSM-5 criteria.
Breath Alcohol Content (BrAC)=0.00 at each visit.
in good health as confirmed by medical history, physical examination and lab tests.
willing to adhere to the study procedures.
understand informed consent and questionnaires in English at an 8th grade level.

Exclusion

• Women who are breastfeeding or positive urine test for pregnancy.
clinically significant medical abnormalities: unstable hypertension, clinically significant abnormal EKG, bilirubin \>150% of the upper normal limit, ALT/AST \>300% the UNL, creatinine clearance ≤60 dl/min
meet DSM-5 criteria for a diagnosis of schizophrenia, bipolar disorder, or other psychoses
medications that reduce alcohol consumption (naltrexone, disulfiram).
use aspirin (salicylates may reduce effect of probenecid), penicillin, methotrexate (may increase concentration).
history of suicide attempts in the last three years.
current diagnosis of a moderate or severe cannabis use disorder as assessed by self-report, SCID-E for SUD, and urine toxicology screen at baseline.
current diagnosis of another substance disorder at any severity, other than nicotine, as assessed by self-report, SCID-E for SUD, and urine toxicology screen at baseline.
current use of medications that may interact with probenecid.
history of hypersensitivity to sulfa drugs.

What this trial measures

  • Acute Alcohol Craving5- week

    Acute alcohol craving during an alcohol cue-reactivity procedure assessed using change in the alcohol urge questionnaire (AUQ). AUQ consists of eight statements about the respondent's feelings and thoughts about drinking as they are completing the questionnaire (i.e., right now). Drinking refers to various types of alcohol, including beer, wine and liquor. The respondent is asked to respond to each statement about alcohol craving via a 7-item Likert scale ranging from "strongly disagree" to "strongly agree." Each item is scored on a 1 to 7 scale (Strongly Disagree = 1 and Strongly Agree = 7). Items 2 and 7 are reverse scored. A total score is computed by averaging the item scores. Minimum score is 7, maximum score is 48. Higher scores reflect greater alcohol craving (worse outcome)