Comparing Irrigating vs. Traditional Negative Pressure Wound Therapy for Necrotizing Soft Tissue Infections

This study is looking at two ways to treat serious skin infections called Necrotizing Soft Tissue Infections (NSTIs). These infections require surgery to remove infected tissue. The study compares standard Negative Pressure Wound Therapy (NPWT), which uses a vacuum to help wounds heal, with Negative Pressure Wound Therapy with Instillation (NPWTi). NPWTi also uses a vacuum but adds hypochlorous acid (a medical-grade dilute bleach) to clean the wound. We want to see if one method leads to fewer unplanned hospital readmissions within 30 days and better healing rates. You might be able to join if you are 18 or older, have a suspected NSTI needing surgery, and are planned to receive a negative pressure wound dressing. The study is currently unclear about its recruitment status and aims to enroll 30 participants.

Study design
This interventional study plans to enroll 30 participants to compare two types of Negative Pressure Wound Therapy.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your healing will be tracked from your first to your last operation, and we will check for unplanned hospital readmissions within 30 days of discharge.

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NCT07120386

Irrigating vs Traditional Negative Pressure Wound Therapy to Treat Necrotizing Soft Tissue Infections

Recruiting
NAAges 18+InterventionalSupportive care
HealthPartners Institute
~30 participants
Updated 2025-09-17 on ClinicalTrials.gov
What's tested:Negative Pressure Wound TherapyNegative Pressure Wound Therapy with Instillation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Unplanned hospital readmission
Measured over Within 30 days of discharge
+1 more outcome measured
Necrotizing Soft Tissue Infections
1 sites across 1 states
Minnesota1
  • Brian S Myer, MD · PRINCIPAL_INVESTIGATOR · Regions Hospital

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Eligibility criteria

Inclusion

Clinical suspicion for Necrotizing Soft Tissue Infection (NSTI) necessitating emergent operative intervention
Age \>/=18 years old
Planned application of a negative pressure wound dressing

Exclusion

Patients who have a wound that does not allow for a wound vac
Patients receiving acute treatment for a NSTI at another institution
Incarcerated patients
Patients who do not survive to wound closure/coverage
Patients \<18 years old
  • Unplanned hospital readmissionWithin 30 days of discharge

    Did the patient have an unplanned readmission to the hospital (Y/N) within 30 days of discharge

  • Rate of healingFirst operation and last operation

    Time from index debridement to final coverage in days