Observational Study of Cervical Cancer and Radiation Therapy Side Effects

This observational study aims to understand how radiation therapy (brachytherapy) affects cervical cancer at a biological level. Researchers want to see if brachytherapy changes the expression of tissue factor and other molecules in cervical cancer over time. You may be able to join if you are a woman aged 18 or older with cervical cancer and are already scheduled to receive brachytherapy. The study is looking for 20 participants. Success for this study means learning more about the molecular pathways in cervical cancer, which could lead to better treatments in the future. The current status of this study is unclear.

Study design
This is an observational study, meaning researchers will watch and collect information without giving new treatments. It plans to include 20 participants.
What's involved
You would provide blood and tissue samples (biopsies) from your cervical cancer or upper vagina before, during, and on the last day of your radiation therapy.
Compensation
Not stated in the trial record.
Follow-up
Tissue factor expression in tumors will be measured at 8 weeks after treatment.

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NCT07121543

Biological Drivers of Cervical Cancer and Side Effects From Radiation Therapy

Recruiting
Not specifiedAges 18+Observational
University of California, San Diego
~20 participants
Updated 2025-08-13 on ClinicalTrials.gov
What's tested:Brachytherapy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Tissue factor expression in tumors
Measured over 8 weeks
Cervical Cancer
1 sites across 1 states
California1
  • Jyoti Mayadev, MD · PRINCIPAL_INVESTIGATOR · University of California, San Diego

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Eligibility criteria

Inclusion

Age 18 years or older
Pathological diagnosis of cervical cancer
Scheduled to receive brachytherapy for cervical cancer

Exclusion

Pregnancy or lactation
Inability to provide a tissue sample
  • Tissue factor expression in tumors8 weeks

    Determine the temporal changes of tissue factor expression in the irradiated tumor immune microenvironment.