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Neurofeedback to Reduce Threat Expectancy

This study is testing a new behavioral intervention called Active Real-time fMRI Neurofeedback. This intervention uses real-time functional magnetic resonance imaging (fMRI) to give you feedback on a specific brain connection related to memory control. The goal is to see if this feedback can help reduce how often people experience a return of fear or threat expectations after they've learned to overcome them. You might be able to join if you are a healthy adult between 18 and 50 years old, don't have any psychiatric or neurological conditions, and meet other health requirements. The study will measure how much your threat expectancy returns over time. The current status of this study is unclear.

Study design
This interventional study plans to enroll 40 healthy participants. It compares Active Real-time fMRI Neurofeedback with Sham Real-time fMRI neurofeedback.
What's involved
You will participate in four fMRI sessions. The total time from your first data collection to your final fMRI session will be at most 60 days.
Compensation
Not stated in the trial record.
Follow-up
Your spontaneous recovery behavior will be measured at the beginning of the study and at your fourth fMRI session, which will be at most 60 days after the start of data collection.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07122739

Neurofeedback to Reduce Spontaneous Recovery of Threat Expectancy

Recruiting
NAAges 18–50InterventionalBasic science
Trustees of Princeton University
~40 participants
Updated 2026-02-23 on ClinicalTrials.gov
What's tested:Active Real-time fMRI NeurofeedbackSham Real-time fMRI neurofeedback

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Spontaneous recovery behavior
Measured over Baseline and fourth fMRI session (out of four total fMRI sessions). At most 60 days will elapse between the start of data collection for a participant and their final fMRI session.

Conditions

Healthy

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
New Jersey1

Study leadership

  • Kenneth A. Norman, Ph.D. · PRINCIPAL_INVESTIGATOR · Princeton University

Who to contact

Augustin C. Hennings, Ph.D.
[email protected]
609-258-5032
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adults aged 18-50
No history of psychiatric disorders or neurological disorders affecting the central nervous system.
Are not currently taking psychoactive medication or drugs of abuse.
Must be eligible to enter an MRI (i.e., no permanent metal or medical implants)
Normal color vision
Right-handed
Full reading and writing English comprehension
Must exhibit spontaneous recovery behavior as determined by an experimenter in a prescreening experimental session
Must be able to provide informed consent

Exclusion

Pregnancy (female participants)
Outside of age range
History of psychiatric or neurological disease
Currently taking psychoactive medication or drugs of abuse
Color blindness
Primary left-handedness
Less than full reading and writing English comprehension
Do not exhibit spontaneous recovery behavior as determined by an experimenter in a prescreening experimental session
Refusing to provide informed consent

What this trial measures

  • Spontaneous recovery behaviorBaseline and fourth fMRI session (out of four total fMRI sessions). At most 60 days will elapse between the start of data collection for a participant and their final fMRI session.

    The investigators will assess neurofeedback related changes in behavioral threat expectancy ratings in a discriminatory Pavlovian conditioning task. Spontaneous recovery is taken as the difference in responding to the conditioned stimulus that was paired with an outcome (CS+) vs. the conditioned stimulus that was not paired with an outcome (CS-) during a test of extinction recall following acquisition and extinction learning.