Observational Study of RFA for Dysplastic Barrett's Esophagus
This study is observing patients who are already receiving radiofrequency ablation (RFA) for dysplastic Barrett's Esophagus (BE) or esophageal cancer. RFA is a treatment that uses heat to remove abnormal cells. Researchers want to understand how RFA changes the esophagus by measuring its 'distensibility' (how easily it stretches) and 'mucosal impedance' (how well the lining resists electrical current). This information could help predict how well RFA works and identify potential problems. You may be able to join if you are an adult with a confirmed diagnosis of BE with dysplasia or early-stage esophageal cancer, can take high-dose proton pump inhibitors (like omeprazole), and are willing to undergo multiple rounds of endoscopic treatment. This study is currently unclear on its recruitment status.
- Study design
- This is an observational study, meaning researchers will collect information during your regular treatment. It plans to include 10 participants.
- What's involved
- You would have measurements of your esophagus taken with two different devices during your clinically indicated upper endoscopies while you are receiving RFA treatments.
- Compensation
- Not stated in the trial record.
- Follow-up
- Measurements will be taken every 12 weeks, for up to one year.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Impact of RFA on Esophageal Distensibility and Mucosal Impedance
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Chamil C Codipilly, M.D. · PRINCIPAL_INVESTIGATOR · Mayo Clinic
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Changes in distensibility index (DI)Every 12 weeks, up to 1 year (4 visits)
Change in DI will be measured by functional luminal impedance planimetry (FLIP) during RFA procedure.
- Changes in diameterEvery 12 weeks, up to 1 year (4 visits)
Change in esophageal diameter will be measured by functional luminal impedance planimetry (FLIP) during RFA procedure.