Observational Study of RFA for Dysplastic Barrett's Esophagus

This study is observing patients who are already receiving radiofrequency ablation (RFA) for dysplastic Barrett's Esophagus (BE) or esophageal cancer. RFA is a treatment that uses heat to remove abnormal cells. Researchers want to understand how RFA changes the esophagus by measuring its 'distensibility' (how easily it stretches) and 'mucosal impedance' (how well the lining resists electrical current). This information could help predict how well RFA works and identify potential problems. You may be able to join if you are an adult with a confirmed diagnosis of BE with dysplasia or early-stage esophageal cancer, can take high-dose proton pump inhibitors (like omeprazole), and are willing to undergo multiple rounds of endoscopic treatment. This study is currently unclear on its recruitment status.

Study design
This is an observational study, meaning researchers will collect information during your regular treatment. It plans to include 10 participants.
What's involved
You would have measurements of your esophagus taken with two different devices during your clinically indicated upper endoscopies while you are receiving RFA treatments.
Compensation
Not stated in the trial record.
Follow-up
Measurements will be taken every 12 weeks, for up to one year.

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NCT07126535

Impact of RFA on Esophageal Distensibility and Mucosal Impedance

Recruiting
Not specifiedAges 18+Observational
Mayo Clinic
~10 participants
Updated 2026-03-30 on ClinicalTrials.gov
What's tested:Radiofrequency ablation alone

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Changes in distensibility index (DI)
Measured over Every 12 weeks, up to 1 year (4 visits)
+1 more outcome measured
Dysplastic Barrett's Esophagus
Radiofrequency Ablation
Barrett Esophagus
1 sites across 1 states
Minnesota1
  • Chamil C Codipilly, M.D. · PRINCIPAL_INVESTIGATOR · Mayo Clinic

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Eligibility criteria

Inclusion

Male or female ≥ 18 years of age
Confirmed histologic diagnosis of BE with dysplasia or intramucosal carcinoma (IMCa)
Ability to take high-dose proton pump inhibitor (PPI) therapy (such as omeprazole 40 mg BID)
Willing to undergo multiple rounds of endoscopic eradication therapy (EET) for management of BE (which is the guideline clinical recommendation for management of this disease)

Exclusion

History of esophageal ablation
History of esophageal stricture
History of esophageal or gastric surgery
Pregnancy
History of esophageal cancer treated with radiation or chemotherapy
History of achalasia
History of delayed gastric emptying confirmed by 4-hour gastric emptying study
Received injection of glucagon like peptide 1 agonists within a few days prior to EGD
Adults lacking the capacity to consent for self
  • Changes in distensibility index (DI)Every 12 weeks, up to 1 year (4 visits)

    Change in DI will be measured by functional luminal impedance planimetry (FLIP) during RFA procedure.

  • Changes in diameterEvery 12 weeks, up to 1 year (4 visits)

    Change in esophageal diameter will be measured by functional luminal impedance planimetry (FLIP) during RFA procedure.