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Resistance Exercise Training for Muscle Insulin Sensitivity

This study is looking into how resistance exercise training helps improve how your muscles use insulin and process sugar. Researchers want to understand the exact ways this type of exercise benefits your body. You might be able to join if you are between 30 and 50 years old, are generally inactive (exercise 30 minutes or less, one day a week or less), and your weight has been stable for at least three months. You cannot join if you have certain heart conditions or already exercise regularly. The main goal is to see how resistance exercise training changes muscle protein production over eight weeks. The current recruitment status is unclear, and 16 people are planned to participate.

Study design
This is an interventional study, meaning participants will receive a specific intervention. It plans to enroll 16 participants.
What's involved
Participants will do resistance exercise training three days a week for about one hour each day, over eight weeks.
Compensation
Not stated in the trial record.
Follow-up
Muscle protein synthesis will be measured at the beginning of the study and again after eight weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07128368

Mechanisms of Resistance Exercise Training for Improved Muscle Insulin Sensitivity

Not Yet Recruiting
NAAges 30–50InterventionalBasic science
Mayo Clinic
~16 participants
Updated 2025-12-12 on ClinicalTrials.gov
What's tested:Resistance Exercise Training

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in muscle protein synthesis
Measured over Baseline; 8 weeks

Conditions

Resistance Training

Explore related trials

Insulin Resistance

Where it's being run

1 sites across 1 states
Minnesota1

Study leadership

  • Mark Pataky · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Sedentary (≤30min of physical activity on ≤1 day/week)
Weight stable for ≥3 months prior to study

Exclusion

Active coronary artery disease or heart failure.
Participation in a structured exercise program \> 1 day/week.
A known medical condition that in the judgment of the investigator might interfere with the completion of the protocol such as the following examples:
Abnormal liver function test results (Transaminase \>2 times the upper limit of normal)
Abnormal renal function test results (calculated GFR \<60 mL/min/1.73m2); If on antihypertensive, thyroid, anti-depressant or lipid lowering medication, lack of stability on the medication for the past 2 months prior to enrollment in the study
Uncontrolled thyroid disease (TSH undetectable or \>10 mlU/L); testing required within three months prior to admission for subjects with a goiter, positive antibodies, or who are on thyroid hormone replacement, and within one year otherwise
Abuse of alcohol or recreational drugs
Active tobacco usage
Infectious process not anticipated to resolve prior to study procedures (e.g. meningitis, pneumonia, osteomyelitis).
Uncontrolled arterial hypertension (Resting diastolic blood pressure \>90 mmHg and/or systolic blood pressure \>160 mmHg) at the time of screening.
A recent injury to body or limb, muscular disorder, use of any medication, any carcinogenic disease, or other significant medical disorder if that injury, medication or disease in the judgment of the investigator will affect the completion of the protocol
Active pregnancy
Menopause (defined as absence of menstruation for 12 consecutive months)
Restrictions on Use of Other Drugs or Treatments:
Any other medication believed to be a contraindication to the subject's participation.

What this trial measures

  • Change in muscle protein synthesisBaseline; 8 weeks

    Rate of insulin-stimulated synthesis of individual proteins