Ketones for Opioid Craving Study

This study is looking at whether a ketone supplement can help reduce opioid cravings and withdrawal symptoms for adults with opioid use disorder (OUD) who are starting inpatient withdrawal treatment. Researchers will compare the ketone supplement to a placebo (an inactive drink) to see if it helps with cravings, low mood, and pain. You might be able to join if you are 18-75 years old, have OUD, and are admitted for opioid withdrawal management at Caron Treatment Center. The main goal is to see if the ketone supplement can lower your craving for opioids. The study is currently unclear about its status and plans to enroll 50 participants.

Study design
This is an interventional study comparing a ketone supplement to a placebo in 50 participants. It is designed to see if the supplement can reduce opioid craving and withdrawal symptoms.
What's involved
You would receive either the ketone supplement or a placebo drink three times daily for seven days. You would also complete assessments for mood, pain tolerance, and opioid withdrawal.
Compensation
Not stated in the trial record.
Follow-up
Your craving levels will be measured at the beginning of the study and again on day 7.

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NCT07128524

Ketones for Opioid Craving

Recruiting
PHASE2Ages 18–75InterventionalTreatment
University of Maryland, Baltimore
~50 participants
Updated 2026-08-25 on ClinicalTrials.gov
What's tested:Treatment with Ketone SupplementTreatment with Placebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Tonic Craving (FORCAST) total scores
Measured over Collected at baseline, and day 7
Opioid Use Disorder
1 sites across 1 states
Pennsylvania1
  • Peter Manza, PhD · PRINCIPAL_INVESTIGATOR · University of Maryland, Baltimore

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age 18-75 years
Meets currents DSM-5 criteria for OUD and admitted for opioid withdrawal management treatment at Caron Treatment Center
Willingness to provide signed, informed consent and commit to completing the procedures in the study

Exclusion

Current severe gastrointestinal (GI), liver, or other clinically significant physical disease that may interfere with the intake of the ketone supplement (e.g., sever inflammatory bowel disease, cirrhosis).
Currently taking (within the past two weeks) GLP-1 receptor agonist medications, e.g. semaglutide, which can interfere with the absorption of the ketone supplement
Currently pregnant or lactating, for people of childbearing potential
Judged by the principal investigator. study physician, or their designee to be an unsuitable candidate for the study
  • Tonic Craving (FORCAST) total scoresCollected at baseline, and day 7

    Faceted Opioid Research Craving Assessment for Substance use Treatment (FORCAST) (Opioid Craving): A 26-item assessment of tonic craving that the person reports having felt over the prior one or two weeks. Participants indicate how much they disagree or agree with each statement on a scale that ranges from 0-6, with 0 representing "strongly disagree", 3 representing "neither agree nor disagree", and 6 representing "strongly agree". Higher scores indicate higher levels of craving. The minimum score is 0, and the maximum scores for each of the subscales are as follows: Preoccupation: 24 Negative Reinforcement: 30 Positive Reinforcement: 24 Motivation: 30 Lack of control: 24 Uneasiness: 24 Maximum total score for all subscales = 156