Phase 2 Study of SAR445877 for ICI-refractory Non-Small Cell Lung Cancer

This study is testing a drug called SAR445877 in people with non-small cell lung cancer (NSCLC) that has not responded to previous immunotherapy (ICI-refractory). The main goal is to see how safe SAR445877 is and what side effects it might cause. Researchers also want to find out if SAR445877 can help control the cancer. You might be able to join if you are 18 years or older, have NSCLC that didn't respond to immunotherapy, and are willing to sign an informed consent form. This study aims to enroll 29 participants.

Study design
This is a Phase 2 interventional study, meaning it tests a new treatment in a small group of people. It plans to enroll 29 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your safety and side effects will be monitored through study completion, which is expected to be an average of 1 year.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07133425

A Phase 2 Platform Study of Immunomodulatory Compounds in ICI-refractory Non-small Cell Lung Cancer

Recruiting
PHASE2Ages 18+InterventionalTreatment
M.D. Anderson Cancer Center
~29 participants
Updated 2026-08-20 on ClinicalTrials.gov
What's tested:SAR445877

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Safety and adverse events (AEs)
Measured over Through study completion; an average of 1 year
Non-Small Cell Lung Cancer
ICI-refractory
1 sites across 1 states
Texas1
  • Natalie Vokes, MD · PRINCIPAL_INVESTIGATOR · M.D. Anderson Cancer Center

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  • Safety and adverse events (AEs)Through study completion; an average of 1 year

    Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 5.0