Vaped Phenanthrene Study for Former Smokers
This study is looking at how your body breaks down a chemical called D10-phenanthrene, which is similar to cancer-causing chemicals found in tobacco smoke. We want to see if former smokers process this chemical differently than people who have never smoked. You can join if you are over 21, in good health, have tried vaping, and are either a former daily smoker (quit 1-20 years ago) or have never used tobacco/nicotine products. We will measure certain chemicals in your urine 24 hours after you vape D10-phenanthrene. The goal is to understand why former smokers might still be at higher risk for lung cancer and to find better ways to prevent or treat it.
- Study design
- This interventional study plans to enroll 100 participants, including former smokers and non-smokers. It is not specified if it is randomized or blinded.
- What's involved
- All participants will be asked to vape D10-phenanthrene. Your urine will be collected 24 hours after vaping, and a baseline measurement of TNE will be taken.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your urine will be tested 24 hours after vaping phenanthrene.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Vaped Phenanthrene
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Stephen Hecht · PRINCIPAL_INVESTIGATOR · University of Minnesota
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Urinary Ratio of D10PheT/D9PhOH24 hours after vaping phenanthrene
The ratio of D10-phenanthrene tetraol to D9-phenanthrene phenols in the urine will determine how the lung breaks down a class of cancer-causing chemicals called Polycyclic Aromatic Hydrocarbons (PAHs). The higher this ratio the more the lungs break down these chemicals through harmful pathways, which might increase cancer risk. The lower the ratio the more the lung breaks down the chemicals through safer pathways.
- TNEBaseline measure
Total nicotine equivalents will be measured in the urine samples to confirm that study participants are not using tobacco or nicotine products.