Optimizing Liver MRI Using Breath-Holding With and Without Oxygen

This study is looking at how different breath-holding techniques, with and without extra oxygen, can improve the quality of abdominal Magnetic Resonance Imaging (MRI) scans. Researchers want to see if breath-holding at the end of a breath out (end-expiration) improves image quality and if adding oxygen helps even more by reducing motion in the images. You might be able to join if you are a healthy adult between 18 and 75 years old, can understand instructions, and can stay still during the MRI. The goal is to make MRI images clearer by reducing motion artifacts (blurry areas caused by movement). The study status is currently unclear.

Study design: This is an interventional study with 10 participants. Each participant will try both breath-holding conditions, with and without oxygen, in a random order.
What's involved: You will have a single MRI session lasting about 1 hour. During this time, you will undergo non-contrast abdominal MRI scans using two different breath-hold techniques.
Compensation: Not stated in the trial record.
Follow-up: Image quality will be measured during the single MRI session.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Optimizing Liver MRI Using Breath-Holding With and Without Oxygen

Recruiting

NAAges 18–75Interventional

University of California, San Francisco

~10 participants

Updated 2026-04-13 on ClinicalTrials.gov

What's tested:Breath-hold conditions

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Liver MRI Image Quality (Motion Artifacts)

Measured over During the single MRI session (approximately 1 hour)

Conditions

MRI

MRI Image Enhancement

Where it's being run

1 sites across 1 states

California1

Study leadership

John P Roberts, MD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

Who to contact

John P Roberts, MD

[email protected]

415-353-3677

Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime

Eligibility criteria

Inclusion

Subject must be within 18-75 years of age;

Subject must be able to hear and understand instructions without assistive devices;

Subject must provide written informed consent;

Subject has the necessary mental capacity to understand instructions, and is able to comply with protocol requirements;

Subject is able to remain still for duration of imaging procedure (approximately 30-45 minutes)

Exclusion

Subjects with a weight greater than 499 lbs;

Subjects that have metallic/conductive or electrically/magnetically active implants without Magnetic Resonance (MR) Safe or Magnetic Resonance (MR) Conditional labeling, with the exception of dental devices/fillings, surgical clips, and surgical staples determined to be safe for MRI scanning by a physician investigator;

Subjects that have implants with MR Unsafe labeling;

Subjects that have implants labeled as MR Conditional by the manufacturer for which the allowable conditions are not expected to be achieved by the MR environment or scan protocol;

Subjects who have a contraindication to MRI per the screening policy of the participating site;

Subjects with any respiratory or cardiovascular condition that could compromise safe breath holding;

Subjects who are female and pregnant

What this trial measures

Liver MRI Image Quality (Motion Artifacts)During the single MRI session (approximately 1 hour)
Image quality of liver MRI scans will be assessed by quantifying the degree of respiratory motion artifacts under two breath-holding conditions: Functional Residual Capacity (FRC) alone and FRC with oxygen supplementation. Reduced artifacts indicate improved image clarity and feasibility of the technique. Unit of Measure: Motion artifact score (ordinal scale, e.g., 1-5).

Trialytics