Platelet Volunteers, Longitudinal and Multi-omic Study
This observational study is looking for healthy volunteers to help researchers understand how platelets (a type of blood cell important for clotting and healing) work in healthy people. The study aims to learn more about how platelets clump together, how blood clots, and how genes and proteins are involved. Researchers also want to see how these processes change over time and how they are affected by things like diet, exercise, and weight. The goal is to establish and improve methods for studying platelets and to understand normal platelet function over a long period. They are looking to enroll 400 participants.
- Study design
- This is an observational study involving 400 healthy participants. Researchers will review medical history and ask about family history and medications.
- What's involved
- You would have a clinic visit once every 6 or 7 months for 10 years. You would need to fast for at least 10 hours and avoid aspirin or NSAIDs for 7 days before each blood draw.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 10 years, which is when the primary endpoints are measured.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Platelet Volunteers, Longitudinal and Multi-omic Study
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Andrew D Johnson, Ph.D. · PRINCIPAL_INVESTIGATOR · National Heart, Lung, and Blood Institute (NHLBI)
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Establish and validate technical assays and equipment (e.g. platelet aggregation, hemostasis measurements, methylation, RNA-seq, proteomics and WGS, in vitro iPSC.10 years
To provide a mechanism for collection of tissue samples from healthy volunteers for use in research studies relating to platelet biology.The goal is to obtain blood samples and corresponding derived information to optimize assays, understand variation in these assays due to different sources of variation, and conduct statistical association studies with appropriate designs including cross-sectional analysis, and longitudinal analyses. Environmental variables may include health reports, anthropometric variables, questions on habits and risk factors and medication during the study.
- Establish normal physiologic mechanisms and platelet-related parameters. How these vary longitudinally and are influenced by variables (e.g., reproducibility, fluctuation with changing diet, exercise, weight and other factors.10 years
To provide a mechanism for collection of tissue samples from healthy volunteers for use in research studies relating to platelet biology.The goal is to obtain blood samples and corresponding derived information to optimize assays, understand variation in these assays due to different sources of variation, and conduct statistical association studies with appropriate designs including cross-sectional analysis, and longitudinal analyses. Environmental variables may include health reports, anthropometric variables, questions on habits and risk factors and medication during the study.