NCT07141524
Optimizing Breathing and Blood Flow in Patients Treated With VA ECMO
Enrolling by Invitation
NAAges 18+InterventionalBasic scienceBeth Israel Deaconess Medical CenterInvestigator-initiated
~10 participants
Updated 2026-02-02 on ClinicalTrials.gov
What's tested:Physiology measurements
At a glance
Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
V/Q match
Measured over 1 hour
Conditions
Where it's being run
2 sites across 1 statesMassachusetts2
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
Adults (≥18 years) undergoing mechanical ventilation during peripheral VA ECMO support for cardiogenic shock, cardiac arrest, or refractory heart failure.
On ECMO support for at least 6 hours
Swan-Ganz catheter required as standard clinical care
Clinically stable in the estimation of the study investigator
Exclusion
Contraindications to EIT (e.g., presence of pacemaker or IMPELLA device for electrical interference)
Patients without pulmonary flow (non-pulsatile pulmonary prSessure)
Patients with known pulmonary embolism
Imminent withdrawal of life support
What this trial measures
- V/Q match1 hour
Primary outcome measure: Reduction in shunt fraction (expressed in %) Secondary outcome measure: Reduction in dead space (expressed as volume) Respiratory mechanics will be recorded before and after best PEEP. Ventilation (L/min)/Perfusion (L/min) \[V/Q\] ratio comparing baseline with best PEEP (after PEEP optimization trial).