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NCT07141524

Optimizing Breathing and Blood Flow in Patients Treated With VA ECMO

Enrolling by Invitation
NAAges 18+InterventionalBasic science
Beth Israel Deaconess Medical Center
~10 participants
Updated 2026-08-26 on ClinicalTrials.gov
What's tested:Physiology measurements

At a glance

Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
V/Q match
Measured over 1 hour

Conditions

VA-ECMO

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NCT07141524

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Beth Israel Deaconess Medical Center

    Boston, Massachusettsno site contact published

  • Beth Israel Deaconess Medical Center

    Boston, Massachusettsno site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

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Eligibility criteria

Inclusion

Adults (≥18 years) undergoing mechanical ventilation during peripheral VA ECMO support for cardiogenic shock, cardiac arrest, or refractory heart failure.
On ECMO support for at least 6 hours
Swan-Ganz catheter required as standard clinical care
Clinically stable in the estimation of the study investigator

Exclusion

Contraindications to EIT (e.g., presence of electrical interference)
Patients without pulmonary flow (non-pulsatile pulmonary pressure)
Patients with known pulmonary embolism
Imminent withdrawal of life support

What this trial measures

  • V/Q match1 hour

    Primary outcome measure: Reduction in shunt fraction (expressed in %) Secondary outcome measure: Reduction in dead space (expressed as volume) Respiratory mechanics will be recorded before and after best PEEP. Ventilation (L/min)/Perfusion (L/min) \[V/Q\] ratio comparing baseline with best PEEP (after PEEP optimization trial).