Infrared Photobiomodulation for Drug-Resistant Epilepsy

This study is exploring a new treatment for drug-resistant epilepsy, a condition where seizures continue despite medication. The treatment involves wearing a hat with infrared lights (photobiomodulation) for 30 minutes daily over six months. Researchers want to see if this treatment can reduce your seizure rate and how comfortable it is to use. You might be able to join if you are 18 or older, have drug-resistant epilepsy with at least two seizures per month, and have kept an accurate seizure diary for at least three months. This treatment has shown promise in animal studies, but this is the first time it's being tested in humans. The study is currently unclear on its recruitment status.

Study design
This is an interventional study with a planned enrollment of 13 participants. All participants will receive the photobiomodulation device.
What's involved
You would wear a hat with infrared lights for 30 minutes daily for six months.
Compensation
Not stated in the trial record.
Follow-up
Your seizure rate reduction and tolerability will be measured at six months.

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NCT07145489

Infrared Photobiomodulation in Humans With Epilepsy

Recruiting
NAAges 18+InterventionalTreatment
Beth Israel Deaconess Medical Center
~13 participants
Updated 2026-02-04 on ClinicalTrials.gov
What's tested:photobiomodulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
seizure rate reduction
Measured over 6 months
+1 more outcome measured
Drug Resistant Epilepsy
1 sites across 1 states
Massachusetts1
  • Daniel Goldenholz, MD PhD · PRINCIPAL_INVESTIGATOR · Beth Israel Deaconess Medical Center

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Eligibility criteria

Inclusion

Drug resistant epilepsy
Age 18 or older
Average seizure rate of at least 2 seizures per month
Accurate seizure diary with at least 3 months recorded

Exclusion

Implanted intracranial neurostimulation device (DBS or RNS)
Intracranial shunt
Skin photosensitivity
Cancer on scalp
Taking any medication that can cause photosensitivity
  • seizure rate reduction6 months

    fraction of seizures reduced by therapy assessed by individual baseline rate

  • tolerability of daily photobiomodulation6 months

    Do participants find it reasonable to use the therapy daily or do they request exiting from the study? Do participants report significant side effects as reported by weekly check-ins that make the therapy uncomfortable or intolerable?