Preparedness Through Respiratory Virus Epidemiology and Community Engagement (PREVENT)

This study, called PREVENT, is looking at how respiratory viruses like COVID-19, RSV, and the flu spread in communities. It aims to understand how often people get sick and how effective different ways of testing and tracking these illnesses are. You can get free testing for respiratory infections through this study. If you join, you might also be asked to try out a special app, provide samples for testing, or participate in a sub-study looking at your immune system or how viruses spread in households. The study hopes to enroll 25,000 people of all ages and genders who live in the service areas of the recruitment centers.

Study design: This is an observational study aiming to enroll 25,000 participants. It involves different components, including community testing and ongoing monitoring.
What's involved: You might be asked to use an app, provide a baseline sample, self-collect nasal swabs, and complete surveys. Some participants will collect daily nasal swabs.
Compensation: Not stated in the trial record.
Follow-up: The study will measure the burden and incidence of respiratory illness, as well as implementation effectiveness, over 5 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Preparedness Through Respiratory Virus Epidemiology and Community Engagement

Recruiting

Not specifiedAll AgesObservational

University of California, San Diego

~25,000 participants

Updated 2025-11-04 on ClinicalTrials.gov

What's tested:Component A0Component A1Component A2Component B

At a glance

Recruiting sites

2 of 2 listed sites are recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Burden and Incident of respiratory illness via infection rates & questionnaires

Measured over 5 years

+2 more outcomes measured

Conditions

Respiratory Infection Virus

COVID -19

RSV

FLU

Where it's being run

2 sites across 1 states

California2

Who to contact

Breanna Reyes, MPH

[email protected]

8589454553

Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime

Eligibility criteria

Exclusion

All ages

AND Lives in service area of a recruitment center (i.e., within range of courier pick up)

AND Plans to remain living in a recruitment area for the next 2 years.

Inability to communicate in a language in which consent forms, materials, etc. are available

OR Incarcerated

OR Living in a congregate setting (e.g., assisted living, nursing home, university dormitories with shared bathroom and communal eating facilities)

OR Unable/unwilling to participate in planned data and specimen collections

OR Unable to comply with study procedures, as determined by study investigators

OR Participation in clinical trials of investigational agents for respiratory viral infections during the three months prior to enrollment and for the duration of the study.

Detection of priority respiratory pathogen via laboratory or point-of-care test on the day of eligibility screening or in the previous 5 days, AND

Lives in service area of a recruitment center (i.e., within range of courier pick up), AND

Lives in a household with ≥1 other person and plans to remain in the household for at least the duration of specimen collection (i.e., 14 days), AND

Has not been hospitalized since the date of symptom onset.

Routinely sleep in the same household as index case and slept in household ≥1 night in the 7 days before index case symptom onset, AND

Plan to remain in the household for at least the duration of specimen collection (i.e., 14 days).

There is ≥1 non-ill household member (i.e., asymptomatic and has not tested positive for the virus of the index case) on the day of eligibility screening or in the previous 5 days,

AND all symptomatic persons in the household had a symptom or diagnosis onset date on the day of eligibility screening or in the previous 5 days.

Lives in a congregate setting (e.g., assisted living, nursing home, university dormitories with shared bathroom and communal eating facilities)

Has been hospitalized any time since date of primary case symptom onset

The enrollment visit occurs \>6 days after the first symptom onset of primary case

The primary case in the household is not enrolled

The primary case has been hospitalized any time after the date of symptom onset

What this trial measures

Burden and Incident of respiratory illness via infection rates & questionnaires5 years
Estimate the burden and incidence of respiratory illness in a community-based cohort of children and adults. A primary objective is to estimate the annual incidence of laboratory-confirmed symptomatic infection for primary respiratory viruses of interest (e.g., SARS-CoV-2, influenza A/B, and RSV A/B) stratified by age group (6 months-4 years, 5-17 years, 18-64 years, 65 or more years). The sample size and precision analysis assumes that the annual incidence of symptomatic laboratory-confirmed infections for priority respiratory viruses will range from 2% to 20%. Based on these assumptions, investigators plan to recruit 1,500 participants per age group. For each age group, sample size is calculated to provide a 95% confidence interval for the estimated annual incidence of symptomatic laboratory-confirmed infection with a precision ranging from ±0.5% to ±2% of the point estimate. This precision is contingent on the assumed annual incidence within the specified range (2% to 20%).
Implementation Effectiveness Questionnaire & Interviews5 years
Assess implementation and effectiveness of interventions for respiratory pathogens. Investigators will describe the use of preventive behaviors, vaccination, and use of pharmaceutical interventions among the study participants. Investigators will explore associations between return of test result and preventive behaviors, healthcare seeking, and treatment via qualitative interviews and surveys.
Secondary Infection Rates5 years
Estimate the secondary infection rates of respiratory pathogens in households and evaluate the effect of household, household member characteristics, and behaviors on household transmission. Sites will aim to recruit between 100 and 150 households per site, for a total of 450 households across the network. Assuming an average household size of 5 persons, research staff would recruit 450 index cases and 1800 household contacts.

Trialytics