ICG for Head and Neck Tumors During Surgery

This study is for adults with head and neck cancer (squamous cell carcinoma) who are at risk of their cancer returning. Researchers are looking at whether a special dye called Indocyanine Green (ICG) can help surgeons see tumor tissue better during an operation. You would receive ICG as an injection before surgery, and then imaging would be done during the surgery. The main goal is to see how well ICG helps identify cancer cells. The study is currently recruiting about 30 participants and will last approximately 6 weeks for each person.

Study design
This is an interventional study planning to enroll 30 participants. The phase of the study is not specified.
What's involved
You would have standard medical visits, receive an Indocyanine Green (ICG) injection, and have imaging done during surgery. Your participation in the study would last about 6 weeks.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured from the time of surgery until final pathology results are available, which is about 2 weeks.

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NCT07149207

Intraoperative Molecular Imaging Using ICG for Head and Neck Tumors

Recruiting
PHASE2Ages 18+InterventionalDiagnostic
Medical University of South Carolina
~30 participants
Updated 2026-07-07 on ClinicalTrials.gov
What's tested:Indocyanine Green (ICG)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Estimates of sensitivity and specificity using ICG.
Measured over From time of surgery until final pathology results are available (about 2 weeks)
Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)
Margin Assessment
1 sites across 1 states
South Carolina1
  • Jason Newman, MD, FACS · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina

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  • Estimates of sensitivity and specificity using ICG.From time of surgery until final pathology results are available (about 2 weeks)

    Sensitivity (specificity) will be estimated as the proportion of pathologically positive (negative) samples that do (do not) fluoresce using ICG.