This study is looking at whether taking a Vitamin C supplement can improve gut health and reduce inflammation in adults with obesity. Researchers believe that better vitamin C levels might help prevent "leaky gut," where harmful substances can enter the bloodstream and cause inflammation. You would receive either a Vitamin C supplement (1000 mg/d) or a placebo while following a low vitamin C diet for two separate two-week periods. The main goal is to see if Vitamin C can improve how well your small intestine acts as a barrier. This study is for English-speaking men and women aged 18-50 with a BMI between 30-40 kg/m².

Study design

This is a randomized, double-blind, placebo-controlled crossover study with 34 participants. This means participants are randomly assigned to groups, neither you nor the researchers will know if you're getting the Vitamin C or placebo, and you will try both the Vitamin C and placebo at different times.

What's involved

You would complete two study periods, each lasting two weeks, with a two-week break in between. During these periods, you will follow a low vitamin C diet, track your diet and activity, and provide blood, urine, and stool samples. You will also have a test to measure gut permeability.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint for measuring small intestinal permeability is at day 14 following each 2-week intervention period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.