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Perioperative Opioid Sparing Techniques for Cancer Surgery

This study is looking at different ways to manage pain after cancer surgery to help patients start chemotherapy sooner. It compares three methods: intrathecal morphine (a pain medicine given into the spinal fluid), quadratus lumborum block (an injection near the lower back muscles), and transverse abdominis plane block (an injection in the abdominal wall using a medicine called Exparel mixed with saline). The study wants to see which of these techniques helps patients begin their chemotherapy treatment fastest after surgery. You might be able to join if you are between 18 and 80 years old, having open surgery for certain cancers (foregut, HPB, or colorectal), and are recommended for chemotherapy. The study is currently unclear on its recruitment status and plans to enroll 200 participants.

Study design
This is an interventional study comparing three different pain management techniques. It aims to enroll 200 participants, but the phase and blinding status are not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be assessed on Day 30, Day 60, and Day 90 visits after surgery to see when chemotherapy begins.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07153614

Efficacy of Perioperative Opioid Sparing Techniques on Time to Initiation of Chemotherapy

Recruiting
NAAges 18–80InterventionalTreatment
University of Tennessee Graduate School of Medicine
~200 participants
Updated 2025-09-04 on ClinicalTrials.gov
What's tested:Intrathecal Morphine BlockBilateral Quadratus Lumborum BlockBilateral Transverse Abdominis Plane Block

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Time to initiation of chemotherapy (in days) as deemed by a blinded medical oncologist
Measured over Day of surgery to first chemotherapy session, assessed on (Day 30, Day 60, Day 90 visits)

Conditions

Perioperative Opioid Sparing Techniques

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Colorectal CarcinomaForegut CancerHepatopancreatobiliary Carcinoma

Where it's being run

1 sites across 1 states
Tennessee1

Who to contact

Study Coordinator: Lauren Crawford, MS
[email protected]
865-305-9308
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Exclusion

Absolute Contraindications
Lack of patient consent.
Skin infection at the site of needle insertion. Relative Contraindications
Coagulopathy
Systemic infection
Anatomical distortion
Neuropathy

What this trial measures

  • Time to initiation of chemotherapy (in days) as deemed by a blinded medical oncologistDay of surgery to first chemotherapy session, assessed on (Day 30, Day 60, Day 90 visits)