NCT07155096
Accelerated DMN-Targeted cTBS to Modulate DMN Connectivity
Enrolling by Invitation
NAAges 18–65InterventionalTreatmentVanderbilt University Medical CenterInvestigator-initiated
~40 participants
Updated 2025-09-11 on ClinicalTrials.gov
What's tested:Repetitive Transcranial Magnetic Stimulation
At a glance
Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Functional Connectivity Changes
Measured over From enrollment to the end of MRI, maximum 3 weeks.
Conditions
Where it's being run
1 sites across 1 statesTennessee1
Study leadership
- Heather Ward, MD · PRINCIPAL_INVESTIGATOR · Vanderbilt University Medical Center
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Eligibility criteria
Inclusion
Age between 18-65 years
Diagnosis of either schizophrenia or schizoaffective disorder according to DSM-5 criteria and confirmed by SCID (First et al. 2015)
Must be able to read, speak and understand English
Must be judged by study staff to be capable of completing the study procedures
Participants will be in stable outpatient psychiatric treatment and psychiatrically stable with no recent (within the past 30 days) psychiatric hospitalizations or changes in their psychiatric medication regimens.
Exclusion
• DSM-5 intellectual disability
Substance use disorder (other than nicotine) within the past three months
Current, active suicidal ideation with intent or plan, as assessed by a score of 5 or higher on the Brief Psychiatric Rating Scale question #4 Suicidality.
Positive urine drug screen for illicit substance use that can increase seizure risk (cocaine, benzodiazepines, amphetamine, methamphetamine)
Any history of a progressive or genetic neurologic disorder (e.g. Parkinson's disease, multiple sclerosis, tuberous sclerosis, Alzheimer's Disease) or acquired neurological disease (e.g. stroke, traumatic brain injury, tumor), including intracranial lesions
History of head trauma resulting in any loss of consciousness (\>15 minutes) or neurological sequelae
Current history of poorly controlled headaches including chronic medication for migraine prevention
History of fainting spells of unknown or undetermined etiology that might constitute seizures
History of seizures, diagnosis of epilepsy, or immediate (1st degree relative) family history epilepsy with the exception of a single seizure of benign etiology (e.g. febrile seizures) in the judgment of a board-certified neurologist
Chronic (particularly) uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.)
Any metal in the brain or skull (excluding dental fillings) or elsewhere in the body unless cleared by the responsible covering MD (e.g. MRI compatible joint replacement)
Any devices such as pacemaker, medication pump, nerve stimulator, TENS unit, ventriculo-peritoneal shunt unless cleared by the responsible covering MD
All female participants of child-bearing age will be required to have a pregnancy test; any participant who is pregnant or planning to become pregnant will not be enrolled in the study
Medications will be reviewed by the responsible covering physician and a decision about inclusion will be made based on the participant's past medical history, drug dose, history of recent medication changes or duration of treatment, and use of CNS active drugs. The published TMS guidelines review of medications to be considered with rTMS will be taken into consideration given their described effects on cortical excitability measures.
Any changes in medications or hospitalizations within the past 30 days.
Participants who, in the investigator's opinion, might not be suitable for the study or would be unable to tolerate the study visit
What this trial measures
- Functional Connectivity ChangesFrom enrollment to the end of MRI, maximum 3 weeks.
We will determine if an accelerated inhibitory cTBS protocol targeted to the DMN is associated with a decrease in functional connectivity before and after cTBS