Finerenone and Empagliflozin for Diabetic Kidney Disease in African American Veterans

This study is looking at how two medications, Finerenone and Empagliflozin, might help African American veterans with diabetic kidney disease. Researchers want to understand if these drugs can reduce kidney damage by looking at specific markers (podocyte specific proteins) in urine. You might be able to join if you are an African American veteran between 20 and 90 years old, have type 2 diabetes, and certain levels of kidney function (eGFR between 25-89 mL/min/1.73 m2) and protein in your urine (albuminuria of 30 mg/g or higher). The study aims to enroll 30 participants. The main goal is to see changes in these kidney damage markers after 16 weeks of treatment.

Study design
This is an interventional study with a planned enrollment of 30 participants. The phase of the study is not specified.
What's involved
Participants will take Finerenone 10 mg orally daily or Empagliflozin 10 mg orally daily for 4 months. Urine exosome assays will be measured at 16 weeks.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at 16 weeks.

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NCT07155694

Role of Finerenone in African American Veterans With Diabetic Kidney Disease

Not Yet Recruiting
PHASE4Ages 20–90InterventionalTreatment
Washington D.C. Veterans Affairs Medical Center
~30 participants
Updated 2026-08-21 on ClinicalTrials.gov
What's tested:Finerenone 10 MGEmpagliflozin 10 MG

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Urine Exosome Assay
Measured over 16 weeks
Diabetic Kidney Disease
1 sites across 1 states
District of Columbia1
  • Sabyasachi Sen, MD, PhD · PRINCIPAL_INVESTIGATOR · Washington DC VA Medical Center

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  • Urine Exosome Assay16 weeks

    To study podocyte specific injury markers (podocyte specific proteins, PSP) nephrin, podocalyxin and Wilms'Tumor (WT-1) protein in exosomes urine on empagliflozin or finerenone or combination therapy. Protein western analysis of Exosomes released from Kidney Podocyte is a indicator of kidney Podocyte health. Expressed as a ratio normalized