Observational Study of Phosphorylated Tau Levels in Donated Blood
This observational study is looking at donated human blood plasma samples to understand the levels of a specific protein called phosphorylated tau-217 (pTau217). High levels of pTau217 are linked to Alzheimer's disease (AD). Researchers want to see if some donated blood units have unusually high pTau217 concentrations. The main goal is to find out how common elevated pTau217 levels are in donated blood. This information will help determine if transfusing blood with higher pTau217 might be risky for recipients and if such blood should be avoided in medical use. This study is not testing any new treatments; it's simply analyzing existing blood samples. About 250 plasma samples will be included.
- Study design
- This is an observational, cross-sectional study analyzing about 250 donated human blood plasma samples, including some from people with Alzheimer's disease and normal controls.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary outcomes, including Tau and pTau levels, will be measured at 6 months.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Phosphorylated Tau Levels in Donated Blood
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Zhongcong Xie, M.D., Ph.D. · PRINCIPAL_INVESTIGATOR · The University of Texas Health Science Center, Houston
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Tau and pTau6 months.
Concentration of Tau and pTau217 in plasma.
- Concentration of pTau217 and Tau6 months.
We will use nanoneedle technology to measure the concentration of Tau and pTau217 in collected plasma samples from blood donators.