Phase 1 Study of SL-325 in Healthy Volunteers

This study is testing a new drug called SL-325, which is a DR3 blocking antibody, in healthy volunteers. It's a first-in-human study, meaning it's one of the first times SL-325 is being given to people. The main goal is to check the safety and how well people tolerate SL-325, with measurements taken for about 75 days after the last dose. You might be able to join if you are between 18 and 55 years old, have a body mass index (BMI) between 18 and 32 kg/m2, weigh more than 50 kg, and have normal lab results. The study is currently recruiting about 72 participants.

Study design
This is a randomized, double-blind, placebo-controlled study, meaning some participants will receive SL-325 and others will receive a placebo (normal saline), and neither you nor the study staff will know which you are getting. It will involve about 72 healthy volunteers.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your safety and tolerability will be measured from Day 1 through 75 days after your last dose.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07158437

Phase 1 Study of SL-325 in Healthy Volunteers

Active, Not Recruiting
PHASE1Ages 18–55InterventionalTreatment
Shattuck Labs, Inc.
~72 participants
Updated 2026-04-30 on ClinicalTrials.gov
What's tested:SL-325Placebo (Normal Saline)

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Safety and Tolerability
Measured over Day 1 through 75 days after last dose
Healthy Volunteers

NCT07158437

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Celerion

    Lincoln, Nebraskano site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

This trial hasn't published a contact. View it on ClinicalTrials.gov

  • Safety and TolerabilityDay 1 through 75 days after last dose

    Incidence and severity of treatment-emergent adverse events