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Methylprednisolone for Pain Control After ACL Repair

This study is looking at whether adding a medication called Medrol (methylprednisolone) to the usual pain relief plan after ACL (anterior cruciate ligament) repair surgery can help reduce pain and the need for opioid pain medications. Opioids are strong pain relievers that can have side effects and risks. Researchers want to see if Medrol can improve pain control without causing more problems. You might be able to join if you are between 13 and 50 years old and are having ACL repair or reconstruction surgery using your own tendon. The study will measure your pain using a scale called the Numerical Rating Scale (NRS) at different times for up to 12 weeks after surgery. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 90 participants. Participants will be randomly assigned to either receive Medrol along with other pain medications or a different set of pain medications.
What's involved
You will be assessed before surgery and then at 2 weeks, 6 weeks, 12 weeks, and 1 year after surgery. You will also answer two questions daily on the MyCap app for 14 days after surgery about your pain and for 15 days about your opioid use.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 1 year after surgery at standard clinic appointments.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07158476

Efficacy of Methylprednisolone for Pain Control After ACL Repair

Recruiting
PHASE4Ages 13–50InterventionalSupportive care
St. Louis University
~90 participants
Updated 2025-10-24 on ClinicalTrials.gov
What's tested:Meloxicam 15 mgMedrol 4 MG Oral Tablet Includes Medrol DosepakGabapentin 300 mgHydrocodone 5Mg/Acetaminophen 325Mg TabKetorolac 10 Mg Oral Tablet

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Numerical Rating Scale (NRS) pain scores
Measured over Post-op days 0-14, 2 weeks, 6 weeks, and 12 weeks

Conditions

ACL Surgery
Pain Management

Explore related trials

Injury of anterior cruciate ligament

NCT07158476

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Saint Louis University

    St Louis, Missourino site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Scott Kaar, MD · PRINCIPAL_INVESTIGATOR · St. Louis University

Who to contact

Scott Kaar
[email protected]
314-617-3405
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Patient undergoing ACL repair or ACL reconstruction with tendon autograft
Age 13-50 years old
Able to provide informed consent or parent/legal guardian is able for minors

Exclusion

Concurrent and significant injury to other bones or organs (Injury Severity Score of 4 or greater)
Revision ACL reconstruction
Concomitant additional ligament reconstruction or high tibial osteotomy
A history of alcohol abuse, substance abuse or chronic opioid use (filled opioid medication ×2 within 6 months of the surgery)
A history of renal failure (\<60 mL/min/1.73 m2), liver dysfunction (child class, \>B), severe heart disease (NYHA Class 4), diabetes, neurological or psychiatric diseases that may affect pain perception, and pre-existing immune suppression.
A history or active peptic ulcer disease, gastrointestinal bleeding, or current use of anticoagulation.
Patients currently taking oral or injectable glucocorticoids and those who have taken either within 1 month of the procedure.
Patients who are currently pregnant.
Patients who are unable to undergo the multimodal pain standardized protocol including those with comorbidities or medical allergies precluding the use of corticosteroids, gabapentin, hydrocodone, acetaminophen, ketorolac, and/or meloxicam.

What this trial measures

  • Numerical Rating Scale (NRS) pain scoresPost-op days 0-14, 2 weeks, 6 weeks, and 12 weeks

    Zero is equivalent to no pain and 10 indicates the worst possible pain