Genicular Nerve Block for Knee Pain in the Emergency Department

This study is looking at whether a genicular nerve block (GNB) can help with knee pain in the emergency department. A GNB involves injecting bupivacaine (a numbing medicine) and dexamethasone (a steroid) near nerves in the knee. You could be eligible if you are over 17, have knee pain not caused by an injury, and an X-ray in the emergency department shows no fracture, dislocation, or large fluid buildup. The study will compare the GNB to standard pain relief like acetaminophen or opioids. Researchers will measure your pain level one hour after treatment to see if the GNB is more effective. This study is currently recruiting patients.

Study design
This is an interventional study that will randomly assign about 34 participants to receive either the genicular nerve block or standard care.
What's involved
You would receive either a genicular nerve block or standard pain relief, and your pain level would be measured one hour after treatment.
Compensation
Not stated in the trial record.
Follow-up
Pain level is measured at 1 hour post-enrollment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07158736

Genicular Nerve Block for Knee Pain in the ED

Recruiting
NAAges 18+InterventionalTreatment
University of Pennsylvania
~34 participants
Updated 2026-02-12 on ClinicalTrials.gov
What's tested:Genicular nerve block with bupivacaine and corticosteroidsStandard of Care

At a glance

Recruiting sites
4 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pain level
Measured over 1 hour post-enrollment
Knee Pain

NCT07158736

Where you'd take part

This study runs at 4 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvaniastudy coordinator listed

    Recruiting

  • HUP Cedar

    Philadelphia, Pennsylvaniastudy coordinator listed

    Recruiting

  • Pennsylvania Hospital

    Philadelphia, Pennsylvaniastudy coordinator listed

    Recruiting

  • Pennsylvania Presbyterian Medical Center

    Philadelphia, Pennsylvaniastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Michael M Shalaby, MD · PRINCIPAL_INVESTIGATOR · University of Pennsylvania
Umar Clinical Research Coordinator, AB
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Eligibility criteria

Inclusion

Atraumatic knee pain
\>17 years age
X-ray of the knee obtained in the ED
Initial pain score (numeric rating scale) 5-10

Exclusion

Fracture or dislocation on x-ray
large knee joint effusion identified on x-ray
allergy or contraindication to local anesthetics
History of local anesthetic systemic toxicity after receiving local anesthetics
Pregnancy
Incarcerated
History of knee replacement of affected knee
Concern for septic joint
Overlying cellulitis
Hemodynamic instability
Altered mental status or inability to consent for procedure.
  • Pain level1 hour post-enrollment

    Measured by numeric rating scale: 0 (minimum value) - 10 (maximum value)