Combined tDCS and Cognitive Training for Opioid Use Disorder
This study is looking into whether adding Transcranial Direct Current Stimulation (tDCS) and cognitive training can help people who are already taking medication for Opioid Use Disorder (OUD). tDCS is a device that delivers a small electrical current to a specific part of the brain. Researchers want to see if this combination helps improve brain networks related to reward and decision-making, and also executive functioning (skills like planning and problem-solving). You might be able to join if you are 18 or older, have OUD, are currently on OUD medication, and can follow study procedures. The study aims to enroll 40 participants.
- Study design
- This interventional study plans to enroll 40 participants. It is not specified if it is randomized or blinded.
- What's involved
- Participants will receive 30-minute tDCS stimulation sessions. The study measures effects immediately after the intervention.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoints are measured immediately after the intervention.
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Combined tDCS and Cognitive Training as an Adjunctive Treatment in Opioid Use Disorder
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Jazmin Camchong, PhD · PRINCIPAL_INVESTIGATOR · University of Minnesota
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- tDCS effect on circuit-based target engagement of a prefrontal-incentive salience networkimmediately after the intervention
To assess changes in target engagement, we will measure the change in resting-state functional connectivity (measured as a Pearson correlation coefficient, r) between the prefrontal cortex and the incentive salience network from pre- to post-intervention using a paired t-test. The connectivity metric ranges from a minimum value of -1.0 (perfectly negative correlation) to a maximum value of 1.0 (perfectly positive correlation). Higher scores indicate stronger functional connectivity (greater top-down regulation), representing a better outcome.
- tDCS effect on executive functioningimmediately after the intervention
To assess changes in executive functioning, we will measure the change in executive functioning from pre- to post-intervention using a repeated measures t-test. Cognitive performance will be assessed via a behavioral battery spanning cognitive flexibility, working memory, inhibitory control, and delay discounting (utilizing standardized Pearson assessments and a computerized delay discounting task). Performance metrics across tasks will be converted to standardized z-scores (typically ranging from -3.0 to +3.0). The primary endpoint is the post-intervention mean z-score minus the pre-intervention mean z-score. A positive change score indicates an increase in executive functioning, representing a better clinical outcome.