Real-world Study on Anti-CGRP Drugs for Migraine

This study is looking at how well certain medications work for people with migraine. These medications, called anti-CGRP drugs, include monoclonal antibodies like erenumab, galcanezumab, fremanezumab, and eptinezumab, or gepants like atogepant and rimegepant. Researchers want to see how these drugs affect your monthly headache and migraine days over about two years. You could be eligible if you are an adult diagnosed with migraine and have a prescription for one of these anti-CGRP drugs. This is an observational study, meaning researchers will watch how these drugs are used in real-world settings. The current status of this study is unclear.

Study design
This is an observational study with a planned enrollment of 700 participants. It is not specified if it is randomized or blinded.
What's involved
You will start an anti-CGRP medication and have visits every 6 months for two years. These visits will check how well the medication is working and if you have any side effects.
Compensation
Not stated in the trial record.
Follow-up
You will be observed for two years, with the primary endpoints measured through study completion.

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NCT07159750

Real-world Prospective Study on the Use of Anti-CGRP Drugs in Migraine

Recruiting
Not specifiedAges 18+Observational
Hospital Universitari Vall d'Hebron Research Institute
~700 participants
Updated 2025-09-08 on ClinicalTrials.gov
What's tested:CGRP antibody or gepant

At a glance

Recruiting sites
25 of 26 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Monthly Headache Days and Monthly Migraine Days
Measured over Through study completion, an average of 2 years
Migraine
Episodic Migraine
Chronic Migraine, Headache
26 sites across 14 states
Barcelona5
Spain5
Italy4
Germany2
Florida1
Argentina1
Chile1
Colombia1
  • Patricia Pozo-Rosich, MD, PhD · PRINCIPAL_INVESTIGATOR · Vall d'Hebron University Hospital

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Migraine diagnosis according to ICHD-III.
Prescription of erenumab, galcanezumab, fremanezumab, eptinezumab, atogepant or rimegepant according to prescriptor criteria and reimbursement criteria according to local regulations.
Signature of informed consent.

Exclusion

Presence of headache different from migraine.
Active severe psychiatric condition or cognitive impairment which may affect the ability to consent patient's participation in the study.
  • Change in Monthly Headache Days and Monthly Migraine DaysThrough study completion, an average of 2 years