Azithromycin vs. Doxycycline for Hospitalized Pneumonia Patients

This study is comparing two common antibiotics, Azithromycin and Doxycycline, in adult patients hospitalized with community-acquired pneumonia (CAP). All participants will also receive another antibiotic called a beta-lactam. Researchers want to see which antibiotic, Azithromycin or Doxycycline, is more effective and safer. You might be able to join if you are an adult (over 18) admitted to the hospital with CAP and are already receiving a beta-lactam antibiotic along with either Azithromycin or Doxycycline. The main goal is to see how many days you are free from the hospital within 28 days. The study status is currently unclear.

Study design
This interventional study plans to enroll 1120 adult participants. Participants will receive either Doxycycline or Azithromycin in combination with a beta-lactam.
What's involved
Participants will receive either Doxycycline or Azithromycin, orally or intravenously, for 5-7 days within 12 hours of hospital admission.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, hospital-free days, is measured at 28 days.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07164131

Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams

Recruiting
PHASE4Ages 18+InterventionalTreatment
Mayo Clinic
~1,120 participants
Updated 2026-07-02 on ClinicalTrials.gov
What's tested:DoxycyclineAzithromycin

At a glance

Recruiting sites
1 of 5 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Hospital-free days
Measured over 28 days
Community-acquired Pneumonia
5 sites across 4 states
Minnesota2
Arizona1
Florida1
Wisconsin1
  • Yewande Odeyemi · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Exclusion

High clinical suspicion for Legionella pneumonia
Allergy or contraindication to the use of either azithromycin or doxycycline (usual clinical practice)
Antibiotics not for CAP
Pregnant women (based on clinical assessment as part of standard of care)
Severe CAP as defined by the ATS/IDSA criteria
Corrected QT prolongation (\> 440 ms in men and \> 460 ms in women)
Receiving a different antibiotic (e.g quinolones)
Admission \> 24 hours
Known to be a prisoner
  • Hospital-free days28 days

    Number of days subject remained out of hospital