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Studying Muscle Weakness and Exercise in Women

This study aims to understand how muscle weakness develops when an arm is temporarily immobilized and if exercising the other arm (called cross-education) can help. Researchers will compare women aged 40-65 who have their non-dominant wrist immobilized for 7 days. Some will also do resistance training on their dominant hand during this time. After the immobilization, all participants will complete a 2-week rehabilitation program for the immobilized arm. The main goal is to see how handgrip strength and wrist strength change over time. You might be able to join if you are a woman between 40-65 years old and have a baseline handgrip strength above 16Kg. The study is currently unclear on its recruitment status.

Study design
This is a randomized controlled study with 20 women aged 40-65. Participants will be assigned to either a group that does resistance training or a control group.
What's involved
You would have your non-dominant wrist immobilized with a cast for 7 days. If in the training group, you would do three resistance training sessions with your dominant arm during this week. All participants will then complete a 2-week rehabilitation program (3 sessions per week) for the immobilized arm.
Compensation
Not stated in the trial record.
Follow-up
Your strength will be measured at the start, immediately after immobilization (1 week), and after rehabilitation (3 weeks).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07166198

Mitigating Neural Hypoexcitability and Weakness During Disuse in Women

Recruiting
NAAges 40–65InterventionalBasic science
Kansas State University
~20 participants
Updated 2026-06-10 on ClinicalTrials.gov
What's tested:Wrist immobilizationResistance trainingResistance training rehabilitation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Handgrip Strength
Measured over Baseline, immediately post-immobilization at 1 week, and post-rehabilitation at 3 weeks.
+2 more outcomes measured

Conditions

Muscle Weakness

Explore related trials

Muscle Weakness

Where it's being run

1 sites across 1 states
Kansas1

Study leadership

  • Joshua Carr, Ph.D. · PRINCIPAL_INVESTIGATOR · Kansas State University

Who to contact

Joshua Carr, Ph.D.
[email protected]
785-532-0700
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Women between 40-65 years of age
Baseline handgrip strength \>16Kg

Exclusion

Personal or family history of blood clots
Current use of anticoagulant medications
Neuromuscular or metabolic diseases (e.g., multiple sclerosis, diabetes)
Arthritis
Osteoporosis or osteopenia
History of myocardial infarction within the past year
Chronic pain ≥3/10 for ≥3 months
Uncontrolled hypertension (≥140/90 mmHg)
Upper extremity surgery within the past year
Use of assistive hand or arm device within the past year
Fall involving the upper extremities within the past year
Upper extremity injuries preventing safe participation
Current use of muscle relaxants, benzodiazepines, or similar drugs
Smoking within the past 6 months
History of drug or alcohol abuse within the past year
Severe anxiety or claustrophobia
Pregnancy (current or planned)
Allergies to medical adhesives
High risk of sarcopenia (per SARC-F)
Contraindications to TMS or MRI
Upper-body resistance training within the past 6 months
Inability/unwillingness to refrain from resistance training during study

What this trial measures

  • Handgrip StrengthBaseline, immediately post-immobilization at 1 week, and post-rehabilitation at 3 weeks.

    Maximal handgrip strength (Kg) using an isometric handgrip dynamometer.

  • Wrist Extension StrengthBaseline, immediately post-immobilization at 1 week, and post-rehabilitation at 3 weeks.

    Peak torque (Nm) of the wrist extensor muscles measured using isokinetic dynamometry

  • Wrist Flexion StrengthBaseline, immediately post-immobilization at 1 week, and post-rehabilitation at 3 weeks.

    Peak torque (Nm) of the wrist flexor muscles measured using isokinetic dynamometry.