Study of Airsupra for Acute Asthma in the Emergency Department

This study is looking at whether using Airsupra, an inhaler containing both albuterol and budesonide, can help prevent asthma attacks from coming back after you've been treated in the emergency department (ED) for acute asthma. Researchers want to see if starting Airsupra when you leave the ED can reduce how often you need to return for asthma treatment over the next three months. You might be able to join if you are 18 to 54 years old, have acute asthma, speak English or Spanish, and your ED doctor plans to send you home with a short course of steroids. If you are in the group using Airsupra, you'll need to be willing to use it as your rescue inhaler for three months and show you can use an inhaler correctly. The study aims to enroll about 1860 people, but its current status is unclear.

Study design
This is a randomized controlled trial, meaning participants will be assigned by chance to different groups. The study plans to enroll approximately 1860 participants.
What's involved
If you are in the intervention group, you would use Airsupra as your rescue inhaler for three months. You would also need to demonstrate acceptable inhaler technique.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, acute asthma recurrence, will be measured at 3 months after starting the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07166939

45th Multicenter Airway Research Collaboration

Recruiting
PHASE4Ages 18–54InterventionalTreatment
Massachusetts General Hospital
~1,860 participants
Updated 2026-04-17 on ClinicalTrials.gov
What's tested:Airsupra

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
acute asthma recurrence
Measured over 3 months
Asthma Acute
Asthma Exacerbation
Asthma
Asthma Control Level
1 sites across 1 states
Ohio1

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

acute asthma
age 18.0 to 54.9 years
English and/or Spanish speaking
decision by ED attending to discharge patient to home on short course of systemic corticosteroids
(intervention group only) Willingness to use Airsupra as their rescue inhaler for next 3 months
demonstration of acceptable MDI administration technique
provision of informed consent prior to any study-specific procedures

Exclusion

involvement in the planning and/or conduct of the study
previous enrolment in the present study
prior diagnosis of COPD, chronic bronchitis, or emphysema
use of systemic corticosteroids in the past 2 weeks
participation in another clinical study with an investigational product during the past 4 weeks or the 3 months after enrollment in the current study
concurrent pneumonia
clinically significant cardiovascular disease or clinically significant cancer
patients with known hypersensitivity to Airsupra, albuterol sulfate, budesonide, or any of the excipients of the product
(for women only, by self-report):
currently pregnant
currently breastfeeding,
(among sexually active women of child-bearing age only) not using adequate contraception over the last 3 months, or no plan to use adequate contraception over the next 3 months
lack of a working cell phone and working email address
expected lack of availability for text and/or telephone follow-up at approximately 3, 6, and 12 weeks after the ED visit
inability to provide an alternate contact with a working cell phone and working email address.
  • acute asthma recurrence3 months

    any urgent or unscheduled visit to a clinician for worsening asthma symptoms during the 3 months after the index ED visit