First-in-Human Study of VNT-101 for Influenza

This study is testing a new oral medication called VNT-101 for influenza (the flu). VNT-101 works by stopping the influenza virus from making more copies of itself. Researchers want to learn about the safety of VNT-101, how well your body tolerates it, and how it moves through your body. The study will involve about 78 healthy adults between 18 and 59 years old. Participants will receive either VNT-101 or a placebo (an inactive pill). The main goal is to see if VNT-101 causes any changes in your heart readings (ECG), lab tests, or vital signs (like blood pressure or heart rate) over 13 days. The current status of this study is unclear.

Study design
This is a Phase 1, randomized, double-blind, placebo-controlled study involving about 78 healthy adults. It has two parts: one testing single doses and another testing multiple doses of VNT-101.
What's involved
You would need to provide written informed consent, be available for all study visits, and comply with all planned trial procedures. The study measures changes from baseline in ECG, lab parameters, and vital signs from Day 1 through Day 13.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints are measured from Day 1 through Day 13, indicating a follow-up period of at least 13 days after the start of treatment.

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NCT07169318

First-in-Human Study of VNT-101: Safety, Tolerability, and Pharmacokinetics

Recruiting
PHASE1Ages 18–59InterventionalTreatment
National Institute of Allergy and Infectious Diseases (NIAID)
~78 participants
Updated 2026-05-11 on ClinicalTrials.gov
What's tested:Placebo for VNT-101VNT-101

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Grade change from baseline in any 12-lead ECG reading
Measured over Day 1 through Day 13
+3 more outcomes measured
Influenza
1 sites across 1 states
Kansas1

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Acceptable methods of contraception include abstinence from intercourse with a female of childbearing potential or use of male condoms with spermicide or surgical sterilization (vasectomy) of participant at least 26 weeks before the Screening.
  • Grade change from baseline in any 12-lead ECG readingDay 1 through Day 13
  • Grade change from baseline in any clinical laboratory parameterDay 1 through Day 13
  • Grade change from baseline in any vital signDay 1 through Day 13
  • Incidence of Treatment Emergent Adverse Events (TEAEs)Day 1 through Day 13