Lu-177 PSMA Therapy for Patients with Kidney or Bone Marrow Issues

This study is looking at how the treatment Lu-177 PSMA (also known as Pluvicto) works in patients who have prostate cancer and also have kidney problems or issues with their bone marrow. Researchers want to understand how much of the Lu-177 PSMA medicine is absorbed by tumors and other organs in these patients. You might be able to join if you are approved for Pluvicto therapy and have certain levels of kidney (renal) complications or compromised bone marrow function, which means your white blood cell (WBC) or platelet counts are outside a normal range. The main goal is to check the safety and any side effects (adverse events) of the treatment over about one year. The study is currently unclear on its recruitment status and plans to enroll 25 men.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It aims to enroll 25 participants.
What's involved
You will receive Lu-177 PSMA through an IV and undergo SPECT/CT scans. The study will monitor your safety and side effects for about one year.
Compensation
Not stated in the trial record.
Follow-up
Your safety and adverse events will be measured through study completion, which is an average of one year.

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NCT07169825

Evaluation of Targeted Radionuclide Therapy of Lu-177 PSMA in Patients With Compromised Renal and/or Bone Marrow Function

Recruiting
PHASE4All AgesInterventional
M.D. Anderson Cancer Center
~25 participants
Updated 2026-08-04 on ClinicalTrials.gov
What's tested:Lu-177SPECT

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
safety and adverse events (AEs).
Measured over Through study completion; an average of 1 year
Lu-177 PSMA
1 sites across 1 states
Texas1
  • Guofan Xu, MD · PRINCIPAL_INVESTIGATOR · M.D. Anderson Cancer Center

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Eligibility criteria

Exclusion

Pluvicto therapy patients without renal or marrow function complications
Participants who do not wish to be imaged multiple times as per the study protocol.
Women and children since this is treatment for prostate cancer.
  • safety and adverse events (AEs).Through study completion; an average of 1 year

    Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 5.0