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7T Brain MRI for Micro-brain Metastasis Detection in SCLC

This study is looking at whether a special type of MRI scan, called a 7T MRI, can find very small brain metastases (cancer that has spread to the brain) earlier in people with small-cell lung cancer (SCLC). You can join if you have SCLC, have chosen not to have prophylactic cranial irradiation (a type of radiation to the brain), and a recent standard MRI (1.5T/3T) showed no brain metastases. The study aims to see if the 7T MRI can detect these metastases sooner than standard scans. The study is currently unclear on its status and plans to enroll 20 participants.

Study design
This is an observational study, meaning researchers will watch and record information without giving new treatments. It plans to include 20 participants.
What's involved
You will have a 7T brain MRI scan. After that, you will continue with your regular standard-of-care 1.5T/3T MRI scans for up to 12 months, or until brain metastases are found.
Compensation
Not stated in the trial record.
Follow-up
You will be followed for up to 12 months after the 7T MRI scan, or until brain metastases are confirmed.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07175077

7T Brain MRI Scan for Micro-brain Metastasis (microBM) Detection for Patients With Small-cell Lung Cancer (SCLC), Who Decline Prophylactic Cranial Irradiation (PCI)

Recruiting
Not specifiedAges 18+Observational
University of Missouri-Columbia
~20 participants
Updated 2025-12-02 on ClinicalTrials.gov
What's tested:7t MRI

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
7t MRI Brain Metastases Detection
Measured over 3, 6, 9, 12 months after 7T MRI

Conditions

Small-cell Lung Cancer
Brain Metastases

Explore related trials

Lung Small Cell Carcinoma

Where it's being run

1 sites across 1 states
Missouri1

Study leadership

  • Bo Lu, MD · PRINCIPAL_INVESTIGATOR · CHAIR & PROFESSOR, DEPARTMENT OF RADIATION ONCOLOGY

Who to contact

Brooke McDaniel
[email protected]
573-884-7488
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patient must have a histologically confirmed diagnosis of small-cell lung cancer (SCLC). • Patient must have an MRI of the brain, performed within 4 weeks prior to consent, documenting no evidence of brain metastases or leptomeningeal disease.
Patient also must not have a history of brain metastases or leptomeningeal disease.
Patient must refuse PCI and agree to surveillance with brain MRI scans (1.5T/3T).
Patient must be ≥ 18 years of age.
Patient must have ECOG Performance Status of 0-2
Patients must be able to tolerate the 7T MRI

Exclusion

Patient must not have a contraindication to an MRI, such as implanted metal devices or foreign bodies.
Patient must not have a contraindication to gadolinium contrast administration during MR imaging.
Patient must not have other metastatic malignancies requiring current active treatment.
Pregnant patients are excluded. Pregnancy status will be confirmed verbally.

What this trial measures

  • 7t MRI Brain Metastases Detection3, 6, 9, 12 months after 7T MRI

    Comparison of 7t MRI to 1.5t/3t to determine if the 7t MRI was able to detect metastases prior to a 1.5t/3t MRI