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SISTER: Comparing IVF Methods with Frozen Donor Sperm

This study, called SISTER, is looking at two different ways to help eggs and sperm fertilize: Intracytoplasmic Sperm Injection (ICSI) and Conventional Insemination (IVF). It's for women undergoing IVF with frozen donor sperm at Shady Grove Fertility Center who do not have male fertility issues. The goal is to see which method leads to more usable embryos (blastocysts) and if there are differences in fertilization rates or early pregnancy outcomes. To join, you need to have normal ovarian reserve (AMH > 1 ng/mL, AFC > 10) and at least 4 eggs retrieved. The study's status is currently unclear.

Study design
This is a randomized study comparing two fertilization methods within the same patient, involving an estimated 95 participants.
What's involved
Participants will have their retrieved eggs divided, with some fertilized by ICSI and others by Conventional Insemination (IVF).
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, blastulation rate, is measured at Day 5 to Day 7 post-insemination.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07175571

SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques

Recruiting
NAAll AgesInterventionalTreatment
Shady Grove Fertility Reproductive Science Center
~95 participants
Updated 2025-09-16 on ClinicalTrials.gov
What's tested:Intracytoplasmic Sperm Injection (ICSI)Conventional Insemination (IVF)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Blastulation Rate
Measured over Day 5 to Day 7 post-insemination

Conditions

Infertility, Female
Reproductive Techniques, Assisted
Fertilization in Vitro

Explore related trials

Female InfertilityNon-Male Factor Infertility

NCT07175571

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Shady Grove Fertility Rockville

    Rockville, Marylandstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Kate Devine, MD · STUDY_CHAIR · Shady Grove Fertility

Who to contact

Allison Eubanks, MD
[email protected]
301-400-2432
Email the study team

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Eligibility criteria

Inclusion

Female patients undergoing IVF with frozen donor sperm at Shady Grove Fertility Center
Normal ovarian reserve (AMH \> 1 ng/mL, AFC \> 10)
Absence of male factor infertility
Post-wash parameters: \>50% motility, \>5mil concentration
\> 4 oocytes retrieved at time of transvaginal oocyte retrieval

Exclusion

Donor Sperm with significant male factor infertility (e.g., abnormal sperm concentration, motility, or morphology)
Any medical condition contraindicating ART

What this trial measures

  • Blastulation RateDay 5 to Day 7 post-insemination

    The blastulation rate is defined as the number of "usable" blastocysts divided by the number of oocytes inseminated in each arm (ICSI and conventional IVF). A blastocyst is considered "usable" if it meets laboratory criteria for either cryopreservation or embryo transfer. Assessment is performed on Days 5-7 after fertilization using standard morphological grading under light microscopy.