Postpartum Preeclampsia Early Detection and Treatment in Nepal

This study aims to improve the early detection and management of preeclampsia (a serious blood pressure condition) that develops after childbirth. You might be able to join if you are pregnant, at least 18 years old, delivering at Dhulikhel Hospital, and have certain risk factors for preeclampsia. Before delivery, your risk will be assessed using a blood test (sFlt-1/PlGF ratio). If you are at high risk, you will be randomly assigned to either receive standard care or a special care bundle. This bundle includes remote blood pressure monitoring, education, and the medication nifedipine ER for mild blood pressure changes. The main goal is to see if these study procedures are practical and well-received. The study is currently recruiting 60 participants, but its overall status is unclear.

Study design
This is a pilot randomized controlled trial involving 60 pregnant patients. Participants at high risk for preeclampsia will be randomly assigned to receive either an intervention bundle or routine postpartum care.
What's involved
You will undergo a preeclampsia risk assessment blood test before delivery. If at high risk, you may receive remote blood pressure monitoring, education, and medication (nifedipine ER) for outpatient management.
Compensation
Not stated in the trial record.
Follow-up
The study's feasibility, which is the primary endpoint, will be measured at 1 year.

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NCT07185204

Postpartum Preeclampsia Early Detection and Treatment: Nepal Pilot Study

Recruiting
NAAges 18+InterventionalPrevention
Medical College of Wisconsin
~60 participants
Updated 2026-07-20 on ClinicalTrials.gov
What's tested:Early detection and management of postpartum preeclampsia bundle

At a glance

Recruiting sites
1 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Study feasibility
Measured over 1 year
Postpartum Preeclampsia
2 sites across 2 states
Wisconsin1
Nepal1
  • Anna Palatnik, MD · PRINCIPAL_INVESTIGATOR · Medical College of Wisconsin

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Eligibility criteria

Inclusion

Pregnant patients ≥ 36 weeks gestation without major fetal anomalies
Age ≥ 18 years
Admitted for labor at Dhulikhel Hospital, or intend to deliver at Dhulikhel Hospital
At risk for preeclampsia, using the Clinical Risk Assessment for Preeclampsia according to ACOG and USPSTF
1 or more high risk factors:
History of preeclampsia
Type 1 or 2 diabetes
Multifetal gestation?
Renal disease
Autoimmune disease
2 or more moderate risk factors:
Nulliparity
BMI \> 30
First-degree relative with a history of preeclampsia
African American race
Low socioeconomic status
Age \> 35 years
History of low birthweight or small for gestational age
Previous adverse pregnancy outcome
Interpregnancy interval \> 10 years

Exclusion

Antenatal hypertensive disorder of pregnancy diagnosis, including gestational hypertension, preeclampsia, eclampsia, or HELLP syndrome, according to ACOG guidelines
Chronic hypertension, according to ACOG guidelines
Known allergy or contraindication to nifedipine
Inability or unwillingness to provide informed consent
Two or more blood pressures with an SBP ≥140 or DBP ≥90 after consent and prior to sFlt-1/PlGF testing (screen failure criteria)
  • Study feasibility1 year

    Assess study feasibility as measured by retention rate.