Advanced Kidney Cancer Study: Fianlimab and Cemiplimab Combinations
This study is for people with advanced kidney cancer (renal cell carcinoma). It's testing different combinations of medicines: fianlimab, cemiplimab, ipilimumab, and nivolumab. You would be randomly assigned to one of three groups. Two groups will receive fianlimab and cemiplimab, with one of those groups also receiving ipilimumab. The third group will receive the standard treatment of ipilimumab and nivolumab. The main goal is to see how many people respond to the treatments after two years. To join, you need to be at least 18 years old and have a good performance status, meaning you can do most daily activities. The study is currently unclear about its recruitment status and plans to enroll 120 participants.
- Study design
- This is a randomized Phase 2 study with three groups, enrolling 120 participants. You would be randomly assigned to one of the treatment groups.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The main goal of the study is measured at 2 years, which suggests follow-up for at least that long.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
A Randomized Trial of Fianlimab and Cemiplimab +/- Ipilimumab or Ipilimumab Plus Nivolumab in First-line Advanced Renal Cell Carcinoma (RCC)
At a glance
Conditions
Where it's being run
3 sites across 3 statesStudy leadership
- Brian Rini, MD · PRINCIPAL_INVESTIGATOR · Vanderbilt-Ingram Cancer Center
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Objective Response Rate (ORR)2 years
ORR is defined as confirmed complete response (CR) + confirmed partial response (PR) and will be determined as per RECIST 1.1.